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Natural Product Research Center

Natural Product Research Center
Objectives
Development of additives to feed and functional food and medicine for infection and inflammatory disease using various kinds of natural products including plant and microorganism and contribution to the development of national bio industry through industrialization of useful bio materials for agriculture, fisheries and livestock raising and technical support for mass production
Researcher
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researchers and research statement
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Young Bae Ryu
/ Associate Director
  • Exploration of natural bio active material, separation, refinement and structural analysis of active material
  • Verification of enzyme activation and kinetic research
Su-Jin Park
/ Principal Researcher
  • Separation and identification of virus that occurs in Korea and research on genetical and phylogenetic analysis on separated virus
  • Research on the development of functional material through verification of anti-viral activation of natural products through in vitro and in vivo test and research on mechanism
  • Pathology, immunohistology, electron microscope research
In Chul Lee
/ Senior Researcher
  • Pharmacology
  • Efficacy evaluation
  • Toxicology
Hyung Jae Jeong
/ Senior Researcher
  • Establishment of mass processing system for biologically active material
  • Research on the application of biologically active material on field
  • Analysis on organic pollutants of natural material and analysis on metabolic products
Ji Young Park
/ Senior Researcher
  • Proteomics, natural product chemistry
Kwon Hyung Jun
/ Researcher
  • Research on virus and anti-virus using ABSL-2/3 animal facility
research areas
  • Development of material that controls infectious diseases using natural products
    • Establishment of biologically active material search system utilizing infectious disease control target factor and verification
    • Securing bio material through screening and establishment of library
    • Research on the adjustment of biologically active candidates activity and mechanism on controlling cell function
    • Verification of safety and efficacy of candidate active material through establishment of infected animal model
  • Securing bio material and establishment of library through establishment of efficient searching system for biological activity deterrent that has anti-viral effect and through screening
    • Verification of the safety and efficacy of candidate material by establishing infected animal model using ABSL-2/3 animal facility
    • Finding out the application point of candidate active material through analysis on the interaction between host and virus
    • Efficient safety and efficacy verification through virus imaging system
  • Development of inflammation control and immunity regulation material using natural material
    • Evaluation on the effect of regulating immunity cell and inflammation cell and mechanism research using in vitro system
    • Verification of the effects of candidate material and research on mechanism using immune disease animal model
  • Securing useful bio material production strain and development of mass production process
    • Improvement of microorganism strain for useful bio material
    • Improvement of microorganism strain for fermented food
    • Mass production of microorganism oriented functional enzyme
    • Development of pesticide degradation microorganism
  • Research on molecular agriculture for plant vaccine and mass production of useful materials based on plant and plant cell culture
    • Development of plant vaccine material and useful material to control livestock disease
    • Development of technology that improves the production of useful material through plant cell culture
    • Development of mass production technology for useful plant cell line material using bio reactor
    • Development of bio resources based on plant cell line in response to Nagoya Protocol
  • Maximization of useful material production through adjustment of plant metabolism flux and metabolism redesigning
    • Exploration of plant metabolic bio synthesis based on omics and development of metabolic regulation technology
    • Maximizing useful metabolome production by connecting to genome editing technology
    • Improving the value of useful material through plant smart cell based bio transformation
    • Identification of major metabolic bio synthesis and relationship between genome and metabolome adjustment using NGS technology
Achievements
  • Refinement of biologically active material from natural material and identification of effective ingredient through structure determination
  • Development of anti-viral activity evaluation assay system
  • Separation of effective ingredient that controls immune reaction obtained from natural bio material and structure determination
  • Development of technology to utilize useful fermented microorganism in industry
  • Identification of antosianin bio synthesis regulation gene and finding out mechanism
  • Development of useful metabolome production increase technology through controlling plant metabolism flux
  • Development of technology to increase production of resveratrol derivatives and commercialization technology through plant cell culture and bio transformation
Outstanding Papers
  • Woo Song Lee and Young Bae Ryu (Co-corresponding) J. yeast Inhib. Med. Chem. 31(1):23-30, 2016.
    • Chalcones isolated from Angelica keiskei inhibit cysteine proteases of SARS-CoV
  • Woo Song Lee (Co-corresponding) Bioorg Med Chem. 22(21):6047-6052, 2014.
    • Structural basis of sialidase in complex with geranylated flavonoids as potent natural inhibitors
  • Young Bae Ryu (First) Acta Crystallogr. D Biol. Crystallogr. 70(5):1357-1365, 2014.
    • Structural basis of sialidase in complex with geranylated flavonoids as potent natural inhibitors
  • Woo Song Lee and Young Min Kim (Co-corresponding) Appl Microbiol Biotech. 97(18):8151-61, 2013.
    • Characterization of a novel steviol-producing beta-glucosidase from Penicillum decumbens and optimal production of the steviol
  • Woo Song Lee and Young Bae Ryu (Co-corresponding) Bioorg Med Chem. 21(13):3730-7, 2013.
    • Dieckol, a SARS-CoV 3CLpro inhibitor, isolated from the edible brown algae Ecklonia cava
  • Woo Song Lee and Su-Jin Park (Co-corresponding) Bioorg Med Chem. 21(15):4706-13, 2013.
    • In vitro antiviral activity of phlorotannins isolated from Ecklonia cava against porcine epidemic diarrhea coronavirus infection and hemagglutination
  • Mun-Chual Rho (Corresponding) J. Pharm. Biomed. Anal. 118:96-100, 2016.
    • Simultaneous determination of 3-O-acetyloleanolic acid and oleanolic acid in rat plasma using liquid chromatography coupled to tandem mass spectrometry
  • Mun-Chual Rho (Corresponding) Phytomedicine. 22(3):415-422. 2015.
    • Salvia plebeia extract inhibits the inflammatory response in human rheumatoid synovial fibroblasts and a murine model of arthritis.
  • Mun-Chual Rho (Corresponding) J Biol Pharm Bull. 38(1):66-74. 2015.
    • Purslane suppresses osteoclast differentiation and bone resorbing activity via inhibition of Akt/GSK3β-c-Fos-NFATc1 signaling in vitro and prevents lipopolysaccharide-induced bone loss in vivo.
  • Mun-Chual Rho (Corresponding) Rheumatology. 53(1):56-64. 2014.
    • Vigna angularis inhibits IL-6-induced cellular signalling and ameliorates collagen-induced arthritis.
  • Mun-Chual Rho (Corresponding) Toxicol Appl Pharm. 269(1):70-80. 2013.
    • Oleanolic acid acetate inhibits atopic dermatitis and allergic contact dermatitis in a murine model
  • Hyun-Mee Oh (Corresponding) Int Immunopharmacol. 25(1):130-140. 2015.
    • Phytocomponent 4-hydroxy-3-methoxycinnamaldehyde ablates T-cell activation by targeting protein kinase C-θ and its downstream pathways.
  • Cha Young Kim (Corresponding) yeast Microb Technol. 54:8-14. 2013.
    • Production of pinostilbene compounds by the expression of resveratrol O-methyltransferase genes in Escherichia coli
  • Cha Young Kim (Corresponding) Plant Physiol Biochem. 89:1-10. 2015.
    • Heterologous expression of IbMYB1a by different promoters exhibits different patterns of anthocyanin accumulation in tobacco