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Biomedical Translational Research Center

Biomedical Translational Research Center
Objectives
Translational research refers to the one which applies findings such as concept, knowledge and technology from basic science research to clinical practices such as diseases diagnosis, treatment and prevention. Key objectives of Biomedical Translational Research Center are to establish key technology and system, and by doing so, to connect findings from basic science to commercial outcomes such as disease diagnosis, treatment, prevention, etc.
  • Establishment of key technology and infrastructure of anti-cancer clinical translational research
  • Studies on structure and function of Intrinsically Unfolded Proteins(IUP)
  • Studies on immunological control of inflammation response
  • Prevention of vessel disease by using protein related to vessel disease and Development of relevant medicine
Researcher
    Click on the name
researchers and research statement
name research fields
Kyung-Sook Chung
/ Director
  • Cancer therapies development
  • mode of action mechanism of cancer Initiating and anticancer drug
Sunghyun Kang
/ Principal Researcher
  • Proteomics and Mass spectrometry
Jae Wha Kim
/ Principal Researcher
  • Efficacy validation of selected candidates for anti-cancer and immune modulation
Yong Beom Shin
/ Principal Researcher
  • Bio-analytical technologies using optoelectronics
  • Developing biosensor for diagnosis and monitoring
Jae-Ran Lee
/ Principal Researcher
  • Neuronal synapse formation and protein tyrosine phosphatases
  • New functions of microglia in synapse formation
Im Sik Chung
/ Principal Researcher
  • Nano-polymer chemistry
Cho-Rok Jung
/ Principal Researcher
  • Functional analysis of genes associated with cancer and its application for therapeutics
Yong-Kyung Choe
/ Principal Researcher
  • Mechanism of cisplatin-resistance
Tai Hwan Ha
/ Principal Researcher
  • Developing nanobiomaterials for biosensor and biochip applications
  • Syntheses of functional materials for biosensing and analytical devices
Kyou Hoon Han
/ Principal Researcher
  • Structural Biology, Intrinsically Unfolded/Disordered Protein (IUP/IDP), NMR Spectroscopy, Peptide Drug, Molecular Computation, Nanoparticle
Tae-Sung Yoon
/ Principal Specialist
  • Neutron & X-ray Crystallography, Structural Proteomics, Space Biology
Yoonkyung Kim
/ Senior Researcher
  • Design and synthesis of functional organic macromolecules for biomedical applications: fluorescence photoswitch, contrast agents, diagnostic and therapeutic agents for tumor and retinal diseases
Hyun Seung Ban
/ Researcher
  • Chemical biology for cancer research
Jung-Hwa Lim
/ Researcher
  • functional analysis of cancer related genes and development of anti-cancer therapeutics (small molecule and gene therapy)
research areas
  • Development of a system for evaluating efficacy of bio based anti-cancer in accordance with international standard
  • Clinical feasibility evaluation of candidates for new anti-cancer medicine
  • Finding therapy target for metastatic tumor and Developing how to control metastatic tumor
  • Development of organoid and networking organoid culture system(NOCS) for alternative animal experiments
  • Building a global database for relations between structure and function of IUP
  • Accumulating and applying clear knowledge of promiscuity and Pre-Structured Motif (PresSMo) which is a key research topic in IUP area
  • Screening new Th 17 differentiation factor from human and mouse
  • Studies on signal transduction of TLR(Toll-like Receptors) from inflammation
  • Research on biosensing technology based on nano-photonics for in-vitro diagnosis
  • Identification of cancer target protein and modulator with multi-functional chemical probes
Achievements
  • Development of key technologies of translational research in order to evaluate efficacy of anti-cancer medicine
    • Development of animal model of orthotropic tumor and of matastatic cancer which can represent tumor micro-environment
    • Proceeding with transition from R&D personnel and organization inside and outside of KRIBB to new drug development organization
  • Establishing observation and concept of IUP and PreSMo initially by a trailblazer (Dr. Han, Gyu Hoon) in the field of IUP in 1995
    • Obtaining order for international joint task between Korea and Hungary and Hosting guest lecture on Asia Pacific Protein Association(APPA)
    • Hosting guest lecture on the 2012 Gorden Research Conference under the them of IUP
  • New hemostatic development and technology transfer
  • System development for analyzing blood clot and thrombolysis
  • Development of ultra-sensitive immunosensing technology based on nanoplasmonics for in-vitro diagnosis