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Anticancer Agent Research Center

Anticancer Agent Research Center
Objectives
Creation of leading material to develop innovative (first in class) anticancer drug and identification of new medicine target by understanding application point target of bioactive materials
  • Identification of new anticancer and cancer metastasis regulation materials
  • Identification of chemical biology based targe and understanding of function
  • Development of carcinogenesis control technology based on protein degradation
  • Synthesizing secondary metabolomics of microorganism and establishment of library for bioactive product of metabolism
Researcher
    Click on the name
researchers and research statement
name research fields
Jong Seog Ahn
/ Associate Director
  • Microbiology, cell biology, chemical biology
Kim Bo Yeon
/ Principal Researcher
  • Cancer cell biology, protein degradation, osteoporosis, radiation cancer biology, stress refractory cancer
Sangku Lee
/ Principal Researcher
  • Organic synthesis natural synthesis and medicinal chemistry
Sungchan Cho
/ Principal Researcher
  • Viral liver cancer
Young-Soo Hong
/ Principal Researcher
  • Biosynthesis of natural product synthesis
  • Synthesis biological engineering of artificial bio synthesis route
Jae-Hyuk Jang
/ Senior Researcher
  • Microorganism natural product chemistry
  • Separation and structural interpretation of metabolic product of land creatures, sea creatures and microorganisms
Nak Kyun Soung
/ Senior Researcher
  • Cell cycle and cancer cell biology, osteoporosis
Sung-Kyun Ko
/ Senior Researcher
  • Understanding of target molecules in the cell of bioactive materials
  • Chemical biology of identifying new medicinal active target in a body
Hyun Joo Cha
/ Senior Researcher
  • Protein degradation, The N-end rule pathway, Autophagy, Cancer
Kyung Ho Lee
/ Researcher
  • Research on cell signal delivery system of cancer causing/spread cell and antenna function in the cell
  • Research on the regulation mechanism of cell cycle related to phosphastase enzyme
In Ja Ryoo
/ Principal Technician
  • Separation and refinement of natural product, analysis from the perspective of cell biology
research areas
  • Identification of anti-cancer and cancer spread candidate materials
    • Identification of effective anticancer materials that control cancer cell specific metabolism
    • Understanding of movement and spread of cancer cell and identification of cancer spread deterrent
  • Understanding of chemical biological target of product of metabolism
    • Analysis on the working of microorganism’s new product of metabolism in a cell
    • Identification of new target molecule in a cell through chemical biological method
  • Exploration of materials that control movement of materials in melanosome in a cell
    • Development of bioactive material that controls autophagy and function of melanosome in a cell
  • Development of technology that controls carcinogenesis based on protein degradation
    • Identification of new anticancer target and anticancer agent by analyzing protein degradation route by N-end rule pathway
  • Microorganism metabolic engineering
    • Identification of the bioactive secondary product of metabolism of microorganism and establishment of library
    • Identification of bioactive secondary product of metabolism through microorganism synthesis biology engineering and metabolism control technology
Achievements
  • Identification of the material that deters movement and permeation of cancer cell
    • Discovery of new bioactive material that has new carbon structure of 5 heterogeneous circular shape in soil fungi isolate (fusarisetin A) and demonstrating that it is an bioactive material that has different mechanism from existing mechanism of cancer cell movement and permeation
  • Development of treatment for neural degenerative diseases, cancer, immune system related diseases by removing cytotoxic protein
    • Finding out the new working principle regarding the protein degradation and change process depending on external environmental change
  • Discovery of compound for skin cancer treatment which has less side effects
    • Discovery of anticancer material that has very low toxicity against the skin cancer derived from carcinogen and ultraviolet ray and synthesis of derivatives
  • Development of Hsp 90 deterrent by redesigning Geldanamycin biosynthesis gene
    • Development of heat shock protein (Hsp) 90 deterrents which is strong and less liver toxicity based on polyketide natural compound of geldanamycin through biosynthesis gene redesigning technology
Outstanding Papers
  • Jae-Hyuk Jang (First) and Jong Seog Ahn (Corresponding) J. Am. Chem. Soc. 133: 6865-6867.
    • Fusarisetin A, an acinar morphogenesis inhibitor from a soli fungus, Fusarium sp. FN080326.
  • Jae-Hyuk Jang and Jong Seog Ahn (Co-corresponding) Org. Lett. 17(16): 4046-4049.
    • Ulleungamides A and B, Modified α,β-Dehydropipecolic Acid-Containing Depsipeptides from Streptomyces sp. KCB13F003.
  • Bo Yeon Kim (Co-corresponding). Nature Cell Biology, 17(7), 917-929.
    • Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding.
  • Bo Yeon Kim (Co-corresponding). Proc. Natl. Acad. Sci, USA, 110(10), 3800-3805.
    • UBR box N-recognin-4 (UBR4), an N-recognin of the N-end rule pathway, and its role in yolk sac vascular development and autophagy.
  • Young-Soo Hong (Corresponding) Cancer Science 105(10): 1245-1253.
    • Anti-tumor activity of WK88-1, a novel geldanamycin derivative, in gefitinib-resistant non-small cell lung cancers with Met amplification.
  • Sangku Lee (Co-A) Tetrahedron Lett. 56, 4349-4353
    • Synthesis of Ramirez ylides from Morita-Baylis-Hillman adducts of a-bromocinnamaldehyde: an intramolecular 1,6-conjugate addition of phosphorus ylide.
  • Sungchan Cho (Corresponding) Oncotarget 5(18): 8515-8527.
    • Efficient lytic induction of Kaposi's sarcoma-associated herpesvirus (KSHV) by the anthracyclines.
  • Nak Kyun Soung (First) Dev. Cell 16 (4); 539-550.
    • Plk1 dependent and in-dependent roles of an ODF2 splice variant hCenexin1 at the centrosome of somatic cells.
  • Sung-Kyun Ko (First) Nat. Chem. 6(10): 885-892.
    • Synthetic ion transporters can induce apoptosis by facilitating chloride anion transport into cells.
  • Kyung Ho Lee (First), EMBO J. 31(14): 3104-3117.
    • Identification of novel Wnt5a-Ck1e-Dvl2-Plk1-mediated primary cilia disassembly pathway.