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Laboratory Animal Resource Center

Laboratory Animal Resource Center
Laboratory Animal Resource Center
Objectives
The goal of our center is to establish a national infrastructures for laboratory animal resources and intramural service core for animal experimentations. For these purposes, we are collecting mouse resources, developing technologies, generating animal models for human diseases, and providing services for researchers in biomedical research fields. We have been collecting, preserving and distributing laboratory animal resources since 1984. We are developing technologies for the quality control of the laboratory animals, generating genetically engineered mice (GEM) and perform in vivo validation of genes associated with human diseases. Recently we have started international cooperation on development of GEM and it’s primary phenotyping to complete mammalian functional genome encyclopedia.
Researchers
    Click on the name
researcher name and research fields
name research fields
Hyoung-Chin Kim
/ Associate Director
  • Experimental Animal Medicine Toxicology Health Safety of LMO
Jong Soon Kang
/ Principal Researcher
  • Molecular Pharmacology
  • Efficacy evaluation of immunomodulatory and anti-cancer agents
Chul-Ho Lee
/ Principal Researcher
  • Development and functional validation of animal models for human metabolic diseases
  • Genetic quality control of laboratory animals
Ki-Hoan Nam
/ Principal Researcher
  • Laboratory Animal Science/Immunology
  • Reproductive engineering/Phenotyping of mutant mice
Won-Kee Yoon
/ Principal Researcher
  • Veterinary Pathology
  • Genetic monitoring of laboratory animals Health Safety of LMO
Young-Suk Won
/ Senior Researcher
  • Bacteriology
  • Health monitoring of laboratory animals
Jung Hwan Hwang
/ Senior Researcher
  • Development of genetically altered laboratory animal models
  • Phenotyoing of functional genes associated with metabolic diseases
Kyoung-Shim Kim
/ Senior Researcher
  • Development and phenotyping of animal models for brain-neurological diseases
  • Discovery of bioactive materials for human brain-neurological diseases
Yong-Hoon Kim
/ Senior Researcher
  • Supports for veterinary care and histopathological analysis
  • Microbiological quality control of laboratory animals
Chang Woo Lee
/ Principal Technician
  • Efficacy evaluation
Hoyoung Ghang
/Researcher
  • Phenotype and genotype association study with mice, new mouse model development
LEE MYUNG YEOL
/ Technician
  • In vivo medicine test
Dong Hui Choi
/ Technician
research areas
  • Laboratory animal resources center
    • Collection, maintenance, and allocation of laboratory animal resources
    • Breeding and distribution of laboratory animal resources to research communities
    • Permanent preservation of laboratory animal resources as frozen resources
    • Establishment of a laboratory animal database
    • Quality control of laboratory animals
    • Phenotyping of mutant mice
    • Development of animal models for human diseases
    • Research supports for animal experiments
    • Functional validation of the genes associated with human diseases
    • Training of laboratory animal techniques
Achievements
  • A highly representative and the largest Korean laboratory animal resource bank
    • Deposits of laboratory animal resources: 465 strains
    • Distribution of laboratory animal resources: 6,252 animals
  • Quality control center for laboratory animals
    • Health monitoring: 2,840 animals
    • Mouse genotyping: 4,446 animals
    • Animal clearing: 41 strains
  • Training in laboratory animal techniques
    • The 35th Laboratory Animal Workshop was held on November 20-21, 2012
  • International cooperation with ICLASand AMMRA
    • ICLAS: International Council for Laboratory Animal Science
    • AMMRA: Asian Mouse Mutagenesis Resource Association
    • AMPC: Asia Mouse Phenotyping Consortium
    • IMPC: International Mouse Phenotyping Consortium
  • Supports for animal experiments
    • Pathological experiment: 37 cases
    • Hematological and biochemical analyses: 73 cases
    • Education service associated with animal ethics and appropriate animal experiments for animal experimenters : 4 times
research activities
  • In 2010, we published 17 papers concerning metabolic diseases (arising from our research using disease animal model resources) and registered 2 patents.
  • Also, we contributed 29 papers for publications resulting from KRIBB research into animal experiment support; including animal husbandry and pathological, hematological and biochemical analyses.
Selected Publications
  • Chul Ho Lee (Corresponding) Cardiovascul Res. 99(4):743-50.
    • NQO1 activation regulates angiotensin-converting enzyme shedding in spontaneously hypertensive rats
  • Chul Ho Lee (Co-corresponding) Diabetes. 62(9):3093-102.
    • Inverse agonist of nuclear receptor ERRgamma mediates antidiabetic effect through inhibition of hepatic gluconeogenesis
  • Chul Ho Lee (Co-corresponding) Gut. 62(7):1044-54.
    • Estrogen-related receptor gamma controls hepatic CB1 receptor-mediated CYP2E1 expression and oxidative liver injury by alcohol
  • Chul Ho Lee (Co-corresponding) Int J Biochem Cell Biol. 45(8):1538-45.
    • The orphan nuclear receptor small heterodimer partner negatively regulates pancreatic beta cell survival and hyperglycemia in multiple low-dose streptozotocin-induced type 1 diabetic mice
  • Chul Ho Lee (Co-corresponding) J Biol Chem. 288(22):15937-46.
    • Insulin directly regulates steroidogenesis via induction of the orphan nuclear receptor DAX-1 in testicular leydig cells