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Disease Target Structure Research Center

Disease Target Structure Research Center
Objectives
Finding out tertiary structure of disease target and creation of orginal technology for function control based on structure
  • Finding out the structure and function of tertiary structure of disease target protein
  • Development of original technology related to function control based on structure of disease target
  • Identification and verification of disease target based on proteomics
  • Research on the control of degenerative diseases based on animal model
Researcher
    Click on the name
researchers and research statement
name research fields
Seung-Wook Chi
/ Associate Director
  • Structural biology of apoptosis adjustment protein, development of medicine based on structure, single molecular biophysics based on Nanopore
Seung Jun Kim
/ Principal Researcher
(Concurrent Position)
  • Research on the antioxidant protein and structure of kinase and phosphastase yeast
  • Development of leading material using tertiary structural information
Jeong Hee Moon
/ Principal Researcher
  • Proteomics using mass spectrography, protein dynamics, quantitative analysis on protein
Byoung Chul Park
/ Principal Researcher
  • Identification and verification of target using proteomics
  • Translational research on immune disease
Sung Goo Park
/ Principal Researcher
  • Role of protein and mechanism related to apoptosis
  • Protease degradomics
Eui-jeon Woo
/ Principal Researcher
  • Research on the structure and function of nucleic acid synthesis protein and Crispr system
  • Development of technology that controls function using structural based proteomics
Kweon Yu
/ Principal Researcher
  • Molecular genetics research on the metabolic diseases and neuroendocrinology using vinegar model
Sunghyun Kang
/ Principal Researcher
  • Proteomics and mass spectrometry
Sun Hong Kim
/ Principal Researcher
  • Development of new medicine through cell signalling research
Tae-Sung Yoon
/ Principal Researcher
  • Neutron & X-ray crystallography, structural proteomics, universe biology
Bonsu Ku
/ Senior Researcher
  • Research on the mechanism by understanding the tertiary structure of proteins in charge of signaling in a cell
Jeong Hoon Kim
/ Senior Researcher
  • Research on mechanism of activity control molecule of protein related to chromatin
  • Screening of epigenome control chemical and screening of synthetic lethality
Jeong Soo Lee
/ Senior Researcher
  • Research on neurology, blood vessel generation and nano toxicity using zebrafish
Mi-Kyung Lee
/ Senior Researcher
  • Research on nucleic acid structural biology, dynamics and research on nanopore analysis
Ho Chul Shin
/ Researcher
  • Research on the structure of protein tyrosine phosphatase and development of antibody
research areas
  • Research on the structure and function of disease target protein
    • Understanding of tertiary structure and mechanism of cell signal regulation protein including apoptosis, cell differentiation and generation of cancer cell using X-ray crystallography and NMR spectroscopy
    • Development of structural based medicine to control disease target
  • Identification and verification of disease target protein based on proteomics
    • Analysis of apoptosis interactome based on proteomics
    • Identification of biomarkers and verification of functions related to atopic skin disease, asthma, and rheumatoid arthritis
  • Research on the degenerative disease control based on animal model
    • Establishment of platform to evaluate the customized multiple digenerative brain disease phenotype animal model (vinegar fly and zebrafish)
    • Research on new candidate material and biomarker mechanism based on animal model related to degenerative disease
  • Development of new drug through cell signaling research
    • Research on various cell signaling mechanisms including GPCR, Wnt, mTOR
    • Identification of effective material and leading material using various activity evaluation methods
  • Research on nanopore based protein and RNA sensing
    • Development of medicine screening technology using nanopore
Achievements
  • Understanding of the tertiary structure and function of kinase and phosphastase yeast
    • Finding out the tertiary structure and mechanism of more than 20 types of phosphastase yeasts that regulate cell signaling including apoptosis, cell differentiation and generation of cancer cell
  • Finding out the structure of protein compound that regulates apoptosis and identification of drug repositioning strategy based on the structure
    • Understanding of tertiary structure of anticancer target protein that regulates apoptosis using NMR spectroscopy and identification of multi-targeting anti-cancer drug
  • Finding out the growth regulating microRNA
    • Finding out that microRNA9a regulates the growth through microRNA library screening
    • Finding out that sNPFR/NPYR is the target of microRNA9a and they regulates growth
  • Presenting the possibility of treating Alzheimer’s disease with porphyrins that is activated by light
    • Finding out that porphyrins activated by light deters the formation of A-beta polymer
    • Finding out that porphyrins activated by light relieves the symptoms in vinegar fly Alzheimer model
  • High resolution imaging analysis in real time on the impact of nano particle graphene oxide on blood vessel development
  • Development of protein-protein interaction deterrent screening technology using nanopore
Outstanding Papers
  • Byoung Chul, Park (Co-corresponding) Cell Death Differ. 2012, 19(1):153-161
    • A critical step for JNK activation: isomerization by the prolyl isomerase Pin1.
  • Sung Goo, Park (Co-corresponding) Cell Death Differ. 2015, 22(10):1605-1617
    • Cell cycle-dependent Cdc25C phosphatase determines cell survival by regulating apoptosis signal-regulating kinase 1.
  • Seung Jun Kim (Co-corresponding) Nat. Struct. Mol. Biol. 2014, 21:696-703.
    • Molecular basis for unidirectional scaffold switching of Plk4 in centriole biogenesis.
  • Seung Jun Kim (Co-corresponding) Acta Crystallographica D. 2014, 70:421-435.
    • The family-wide structure and function of the human dual specificity protein phosphatases.
  • Seung Jun Kim (Co-corresponding) Acta Crystallographica D. 2013, 69: 1522-1529.
    • Structural basis for the dephosphorylating activity of PTPRQ for phosphatidyl inositide substrates.
  • Eui-Jeon Woo (Corresponding) Structure. 2015, 7;23(4):782-90.
    • Crystal structure of the Csm1 Subunit of the Csm complex and its single-stranded DNA-specific nuclease activity.
  • Kweon Yu (Co-corresponding) Nature Communications. 2015, 6:7693.
    • Genome-wide screening reveals that the evloutionary conserved miR-9a regulates body growth by targeting sNPFR1/NPYR.
  • Kweon Yu (Co-corresponding) Angew. Chem. 2015, 54(39):11472-11476.
    • Photoexcited porphyrins as a strong suppressor of β-amyloid aggregation and synaptic toxicity.
  • Seung-Wook Chi (Co-corresponding) Cell Cycle 2015, 14(4):533-543.
    • Structural convergence of unstructured p53 family transactivation domains in MDM2 recognition.
  • Seung-Wook Chi (Co-corresponding) J. Biol. Chem. 2013, 288(10):7387-98.
    • Dual-site interactions of p53 protein transactivation domain with anti-apoptotic Bcl-2 family proteins reveal a highly convergent mechanism of divergent p53 pathways.
  • Seung-Wook Chi (Co-corresponding) J. Am. Chem. Soc. 2011, 133(5):1244-1247.
    • Molecular mimicry-based repositioning of Nutlin-3 to anti-apoptotic Bcl-2 family proteins.
  • Jeong Hee, Moon (First) Mass. Spectrom. Rev. 2015, 34(2):94-115.
    • Formation of gas-phase peptide ions and their dissociation in MALDI: Insights from kinetic and ion yield studies.
  • Tae-Sung, Yoon (Co-corresponding) Acta Crystallographica D. 2013, 69(Pt 4):555-563.
    • Structural and biochemical characterization of the cytosolic wheat cyclophilin TaCypA-1.
  • Sunhong Kim (Co-corresponding) Eur. J. Pharm., 2016, 771, 1-9.
    • Selective novel inverse agonists for human GPR43 augment GLP-1 secretion
  • Jeong-Soo Lee (Co-corresponding) Carbon 2015, 93:431-440.
    • In vivo toxicity assessment of angiogenesis and the live distribution of nano-graphene oxide and its PEGylated derivatives using the developing zebrafish embryo.