Current page location

Disease Target Structure Research Center

Disease Target Structure Research Center
Objectives
Finding out tertiary structure of disease target and creation of orginal technology for function control based on structure
  • Finding out the structure and function of tertiary structure of disease target protein
  • Development of original technology related to function control based on structure of disease target
  • Identification and verification of disease target based on proteomics
  • Research on the control of degenerative diseases based on animal model
Researcher
researchers and research statement
Name Research Fields
Seung-Wook Chi
(Associate Director)
  • Nanopore sensor technology development, protein design and engineering
  • Structure-based drug development, structural biology of apoptosis-regulating anticancer proteins
Seung Jun Kim
  • Structural studies on anti-oxidant proteins and protein tyrosine phosphatases
  • Drug development using 3-D structural information
Jeong Hee Moon
  • Mass spectrometry, Proteomics, Protein Dynamics, Protein Quantification
Byoung Chul Park
  • Target mining and validation using proteomics, Signal transduction
  • Translational research on immune diseases
Sung Goo Park
  • Mechanism and functions of apoptosis-related proteins, Protease degradomics
Eui-Jeon Woo
  • Research on the structure and function of nucleic acid-binding proteins and Crispr system
  • Development of functional control technology using structure-based protein engineering
Kweon Yu
  • Molecular genetics research on metabolic and neurodegenerative diseases using the Drosophila Model
Sunghyun Kang
  • Proteomics and mass spectrometry
Sunhong Kim
  • Cell Signal Transduction in cell and C. elegans model
  • Drug Discovery
Tae-Sung Yoon
  • Neutron & X-ray crystallography, structural proteomics, astrobiology
Bonsu Ku
  • Protein X-ray crystallography
  • Structural studies on signaling-regulatory proteins
Jeong Hoon Kim
  • Studies on the regulatory mechanisms of chromatin modifiers
Jeong-Soo Lee
  • Research on neurology, blood vessel development, and nanotoxicity using zebrafish
Mi-Kyung Lee
  • Structural and dynamics studies using NMR spectroscopy
  • Analysis of biomolecule using solid-state and protein nanopores
Ho-Chul Shin
  • Protein X-ray crystallography
  • 3D structural studies and antibody development of protein tyrosine phosphatases
research areas
  • Research on the structure and function of disease target protein
    • Understanding of tertiary structure and mechanism of cell signal regulation protein including apoptosis, cell differentiation and generation of cancer cell using X-ray crystallography and NMR spectroscopy
    • Development of structural based medicine to control disease target
  • Identification and verification of disease target protein based on proteomics
    • Analysis of apoptosis interactome based on proteomics
    • Identification of biomarkers and verification of functions related to atopic skin disease, asthma, and rheumatoid arthritis
  • Research on the degenerative disease control based on animal model
    • Establishment of platform to evaluate the customized multiple digenerative brain disease phenotype animal model (vinegar fly and zebrafish)
    • Research on new candidate material and biomarker mechanism based on animal model related to degenerative disease
  • Development of new drug through cell signaling research
    • Research on various cell signaling mechanisms including GPCR, Wnt, mTOR
    • Identification of effective material and leading material using various activity evaluation methods
  • Research on nanopore based protein and RNA sensing
    • Development of medicine screening technology using nanopore
Achievements
  • Understanding of the tertiary structure and function of kinase and phosphastase yeast
    • Finding out the tertiary structure and mechanism of more than 20 types of phosphastase yeasts that regulate cell signaling including apoptosis, cell differentiation and generation of cancer cell
  • Finding out the structure of protein compound that regulates apoptosis and identification of drug repositioning strategy based on the structure
    • Understanding of tertiary structure of anticancer target protein that regulates apoptosis using NMR spectroscopy and identification of multi-targeting anti-cancer drug
  • Finding out the growth regulating microRNA
    • Finding out that microRNA9a regulates the growth through microRNA library screening
    • Finding out that sNPFR/NPYR is the target of microRNA9a and they regulates growth
  • Presenting the possibility of treating Alzheimer’s disease with porphyrins that is activated by light
    • Finding out that porphyrins activated by light deters the formation of A-beta polymer
    • Finding out that porphyrins activated by light relieves the symptoms in vinegar fly Alzheimer model
  • High resolution imaging analysis in real time on the impact of nano particle graphene oxide on blood vessel development
  • Development of protein-protein interaction deterrent screening technology using nanopore