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Korea National Primate Research Center

Korea National Primate Research Center
Objectives
Supporting for primate resources and materials and supporting for the development of new drugs for rare disease and bio organs and regenerative medicine through the establishment of research foundation for primate at the national level
  • Securing, increasing and spreading SPF primate resources
  • Standardization and establishment of professional technology of primate for research purpose
  • Support for the industry-academia-research institute research on primate and pursuing joint research
  • Research on the development of disease model using primate
  • Research on the effectiveness of bio organs, regenerative medicine and bio new drugs
Researchers
    Click on the name
researcher name and research fields
name research fields
Sang-Rae Lee
/ Associate Director
(Concurrent Position)
  • Evaluation on the effectiveness and support for basic science research using nonhuman primates
  • Development of brain disease primate model and research support
Kim Young-Hyun
/ Senior Researcher
  • Monitoring of nonhuman primate microorganism
  • Research on nonhuman primate genome
  • Identification of nonhuman primate gene and analysis of function
Kim Ji-Su
/ Senior Researcher
  • Research on the heterogeneous transplant using transformational animal model
  • Research on the molecular regulation of early ovogenesis
  • Research on developmental engineering using primate/mini pig
Jae Won Huh
/ Senior Researcher
  • Research on functional genomics and evolutionary biology through genomics research
  • Research on primatology
Lee Young Jeon
/ Senior Researcher
  • Development of primate brain disease model and analysis of pathology
Yeung Bae Jin
/ Senior Researcher
  • Veterinary pathology
Jung Joo Hong
/ Senior Researcher
  • Primate immunity
Bon-Sang Koo
/ Researcher
  • Preventive Veterinary Medicine
Sang Je Park
/ Researcher
  • Molecular genetics
JONG-HEE LEE
/ Researcher
  • Stem cell isolation/characterization support
  • Stem cell-based blood regeneration
Baek Seung Ho
/ Researcher
  • Radiology
Young Hoon Son
/ Researcher
  • Veterinary Anatomy and Histology
Dong-Ho Lee
/ Researcher
  • Laboratory Animal Science(Nonhuman Primates)
Bo Woong Sim
/ Principal Technician
(Concurrent Position)
  • Animal developmental engineering
Kang Jin Jeong
/ Senior Technician
  • Securing, increasing and maintaining disease free primate and mini pig
  • Establishment of colony through self reproduction
  • Support for test using primate (PK, ovulation induction. AD, PD and stroke)
Ki Jin Kim
/ Technician
  • Raising, reproducing and managing primate
  • Support for test using primate (PK, ovulation induction. AD, PD and stroke)
Seung-Bin Yoon
/ Technician
  • Establishment of SPF monkey massive production system for Industrial-academical-institutional support
Sang Il Lee
/ Technician
  • Raising, reproducing and managing primate
  • Support for test using primate (PK, ovulation induction. AD, PD and stroke)
Hwal Yong Lee
/ Technician
  • Raising, reproducing and managing primate
  • Support for test using primate (PK, ovulation induction. AD, PD and stroke)
Chang Yeop Jeon
/ Technician
  • Raising, reproducing and managing primate
  • Support for test using primate (PK, ovulation induction. AD, PD and stroke)
research areas
  • Securing/reproducing and supplying specific pathogen free (SPF) primate resources
    • After securing and reproducing SPF primate, providing it to industry, academia and \ research institute
  • Standardization of handling and laboratory requirement for primate research
    • Maintaining standard level of primate resources by monitoring germ, virus and general health indicators Establishment of standard operation policy (SOP) for the growing and managing primate resources at the international level
  • Research on heterogeneous transplant
    • Transplanting organs of germ-free transformational pig to SPF primate (ex. pancreatic islet, heart) and analysis on the effectiveness and safety of transplanted organs
  • Research and application of regenerative medicine
    • Using primate disease model in cell therapy and gene therapy and evaluation on the effectiveness and safety in rare disease
  • Evaluation of pre-clinical effectiveness of newly developed new drug candidate
    • Application of various bio medicines and bio materials to SPF primates to evaluate effectiveness
  • Evaluation the immunogenicity and safety of vaccine candidate
    • Evaluation on the immunogenicity, safety and effectiveness of various vaccines and AIDS vaccine test
  • Development of disease model
    • Development of application technology for new drug and research on organs and regenerative medicine by developing rare disease model of primates which have the most similar metabolic route to that of human
  • Cooperation and support for domestic researchers related to primates
    • Providing technology and information related to management and facility of primates to other researchers and conducting joint research to develop relevant technologies
Achievements
  • Securing primate resources
    • Primates provide a valuable opportunity as it provides nonhuman biological and antanomical data necessary for biomedicine research and its application. Our center secured 6 types of SPF primates (Rhesus monkeys, Cynomolgus, African green monkeys, Japanese monkeys, Squirrel monkeys and Common marmoset) and the total number of them is 400.
  • Selling primate resources and technology transfer to domestic industry academia research institute cooperative body
    • The center shares its expertise on primate with researchers in other fields including geonomics, cerebral nerve science and drug dynamics. We are providing service to maintain SPF primates including individual training through workshop on the monitoring, quarantine and management from microorganism perspective and training to those including veterinarian and keeper who deal with primates
  • Cooperation with domestic and overseas researchers
    • Our center is conducting joint research with researchers in domestic and overseas industry, academia, research institute and military on the development of disease model and evaluation of treatment medicine dynamics related to stroke, alzheimer‘s disease and Parkinson’s disease
Outstanding Papers
  • Sun-Uk Kim and Kyu Tae Chang (Co-corresponding) Biol Reprod. 87(1):8, 1-11.
    • Induction of autophagy promotes preattachment development of bovine embryos by reducing endoplasmic reticulum stress
  • Kyu Tae Chang (Corresponding) BMC Genomics. 13:163.
    • Large-scale transcriptome sequencing and gene analyses in the crab-eating macaque (Macaca fascicularis) for biomedical research
  • Kyu Tae Chang (Co-corresponding) J Pineal Res. 52(1):107-19.
    • Beneficial effects of endogenous and exogenous melatonin on neural reconstruction and functional recovery in an animal model of spinal cord injury