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National Primate Research Center

National Primate Research Center
Objectives
Supporting for primate resources and materials and supporting for the development of new drugs for rare disease and bio organs and regenerative medicine through the establishment of research foundation for primate at the national level
  • Securing, increasing and spreading SPF primate resources
  • Standardization and establishment of professional technology of primate for research purpose
  • Support for the industry-academia-research institute research on primate and pursuing joint research
  • Research on the development of disease model using primate
  • Research on the effectiveness of bio organs, regenerative medicine and bio new drugs
Researchers
researcher name and research fields
Name Research Fields
Yeung Bae Jin
(Associate Director)
  • Pathologic diagnosis and veterinary clinical care for nonhuman primates
  • Development and preclinical evaluation of nonhuman primate models for human disease
Sang-Rae Lee
  • Development of brain disease models (Stroke, Dementia, Parkinson’s disease) with nonhuman primates
  • Establishment of efficacy test system with brain disease models
  • Development of infectious disease models with nonhuman primates
Jae-Won Huh
  • Human and nonhuman primate comparative genomics
  • Molecular genetics & Primatology
  • Identification and molecular characterization of nonhuman primate genes
Young-Hyun Kim
  • Maintaining quality standards of nonhuman primate resources by SPF health monitoring
  • Comparative analysis of human and nonhuman primate genome
  • Identification and molecular characterization of nonhuman primate genes
Ji-Su Kim
  • Development of transgenic animal models in Xenotransplantation research and support
  • Establishment of developmental biotechnology and regenerative medicine in non-human primates
  • Development and derivation of research resources from non-human primates
Youngjeon Lee
  • Neuroscience and behavioral science
  • Development and preclinical evaluation of nonhuman primate models for Alzheimer's disease and Parkinson's disease
Jung Joo Hong
  • Comparative immunology of human and nonhuman primates
  • Understanding the immunologic mechanisms in immunization and vaccination using infectious model of nonhuman primate
  • Analyzing the safety and efficacy of immune modulator in vitro and in vivo nonhuman primate model
Bon-Sang Koo
  • Veterinary preventive medicine
  • Veterinary clinical diagnosis and care for nonhuman primates and minipigs
  • Pathologic and molecular characterization of infectious agents using in vitro and in vivo systems including minipigs and nonhuman primates
  • Biosafety management of animal biosafety level 3 facility
Sang-Je Park
  • Virus monitoring of SPF primate
  • Molecular genetics of human and nonhuman primates
  • Quantitative analysis of various species’ genes
Seung Hwan Lee
  • Development of an effective transgenic animal model with target-specific genome engineering
  • Development of disease model and therapeutic agent by using nonhuman primates and minipigs
  • Development of minipig models for heterologous organ transplantation
Jong-Hee Lee
  • Stem cell biology of nonhuman primates and minipigs
  • Understanding of developmental and disease mechanisms and provision of new therapeutics using stem cell technology from nonhuman primate and minipig models
Seung-Ho Baek
  • Molecular imaging using PET-CT
Bo-Woong Sim
  • Establishment of micromanipulation system for generation of transgenic mini-pigs
  • Development of advanced cloning technology in mini-pigs
Kang-Jin Jeong
  • Reproduction and maintenance of SPF primates
  • Quarantine of nonhuman primates
  • External support service
Hwal-Yong Lee
  • Reproduction and maintenance of SPF primates
Chang-Yeop Jeon
  • Bio-medical engineering & radiology
  • MR imaging in development of brain disease models (Stroke, Alzheimer's disease and Parkinson's disease) with nonhuman primates
research areas
  • Securing/reproducing and supplying specific pathogen free (SPF) primate resources
    • After securing and reproducing SPF primate, providing it to industry, academia and \ research institute
  • Standardization of handling and laboratory requirement for primate research
    • Maintaining standard level of primate resources by monitoring germ, virus and general health indicators Establishment of standard operation policy (SOP) for the growing and managing primate resources at the international level
  • Research on heterogeneous transplant
    • Transplanting organs of germ-free transformational pig to SPF primate (ex. pancreatic islet, heart) and analysis on the effectiveness and safety of transplanted organs
  • Research and application of regenerative medicine
    • Using primate disease model in cell therapy and gene therapy and evaluation on the effectiveness and safety in rare disease
  • Evaluation of pre-clinical effectiveness of newly developed new drug candidate
    • Application of various bio medicines and bio materials to SPF primates to evaluate effectiveness
  • Evaluation the immunogenicity and safety of vaccine candidate
    • Evaluation on the immunogenicity, safety and effectiveness of various vaccines and AIDS vaccine test
  • Development of disease model
    • Development of application technology for new drug and research on organs and regenerative medicine by developing rare disease model of primates which have the most similar metabolic route to that of human
  • Cooperation and support for domestic researchers related to primates
    • Providing technology and information related to management and facility of primates to other researchers and conducting joint research to develop relevant technologies
Achievements
  • Securing primate resources
    • Primates provide a valuable opportunity as it provides nonhuman biological and antanomical data necessary for biomedicine research and its application. Our center secured 6 types of SPF primates (Rhesus monkeys, Cynomolgus, African green monkeys, Japanese monkeys, Squirrel monkeys and Common marmoset) and the total number of them is 400.
  • Selling primate resources and technology transfer to domestic industry academia research institute cooperative body
    • The center shares its expertise on primate with researchers in other fields including geonomics, cerebral nerve science and drug dynamics. We are providing service to maintain SPF primates including individual training through workshop on the monitoring, quarantine and management from microorganism perspective and training to those including veterinarian and keeper who deal with primates
  • Cooperation with domestic and overseas researchers
    • Our center is conducting joint research with researchers in domestic and overseas industry, academia, research institute and military on the development of disease model and evaluation of treatment medicine dynamics related to stroke, alzheimer‘s disease and Parkinson’s disease