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Korea Biosafety Clearing House

Korean Bioinformation Center

Korean Bioinformation Center

Objectives
The Korean Bioinformation Center (KOBIC) is the national research center for bioinformatics which plays a key role in various areas such as genomics, proteomics, systems biology, and personalized medicine. KOBIC is also responsible for the integration and management of bioresource/biodiversity information from various research laboratories and institutions across the country.
KOBIC provides a centralized data access portal to promote sharing and utilization of the data among research groups.
Researchers
    Click on the name
researchers and research statement
name research fields
Yong-Kyung Choe
/ Associate Director
  • Mechanisms of cisplatin-resistance
Jang-Seong Kim
/ Associate Director
/(Concurrent Position)
  • Development of anticancer agents, research on matastasis, development of new drug
In-Sun Chu
/ Principal Researcher
  • Biomedical informatics
Byungwook Lee
/ Principal Researcher
  • Processing NGS data gene expression analysis and epigenomic regulation
Bo Kyeng Hou
/ Senior Researcher
  • Systems biology and chemoinformatics
Seungwoo Hwang
/ Senior Researcher
  • Systems bioinformatics and gene expression data analysis
Tae Eun Jin
/ Senior Researcher
  • Steering a ABS help-desk
  • Researching laws, regulations, and current international trends on ABS
Jinhyuk Lee
/ Senior Researcher
  • Structural Biology
  • Molecular Modeling
Jin Ok Yang
/ Senior Researcher
  • Development and analysis of miRNA expressions
  • Controlled studies of complex diseases and different cancer types
  • Development of a system for transient analysis of chromatin structure
Kim, Yong-Min
/ Researcher
  • Bioinformatics (Genome analysis)
KIM SE-JOO
/ Researcher
  • systematics
Iksu Byeon
/ Researcher
  • Overall management of Computational Infrastructure in KOBIC
Pan-Gyu Kim
/ Researcher
  • Computer Science, Bioinformatics, Algorithm, Cloud Computing
Seongjin Park
/ Researcher
  • Bioinformatics
research areas
  • Bioresource Information Unit
    • Construction of an integrated information system for national bioresources
    • Development of national data standards
    • Building national collaborations and liaison networks
  • Genome Information Analysis Unit
    • Genome, transcriptome, and proteome analysis of human diseases
    • Network-based analysis of multi-omics data
    • Design and construction of integrated pipeline for multi-omics data
    • Genome sequencing and analysis of biological resources
  • Genome Information Development Unit
    • Construction and development of biological databases
    • Development of bioinformatics algorithms/tools and systems
    • Development of omics analysis methods/systems
  • NGS Integrative Analysis Unit
    • De novo genome assembly and their comparative genomics studies
    • De novo transcriptome assembly and association with diseases
    • Genome mutation analysis for rare disease and cancer genomes
    • Genome variation analysis and population studies & genetics
  • Computer Infrastructure Team
    • Management and development of servers, clusters, and storage systems
    • Support for developing web-based solutions and applications
    • Implementation of supercomputing infrastructure for Big Data
  • Biomedical Informatics Team
    • Biomedical informatics for multi-omics data analysis
    • Development of integrated analysis system of cancer genome data
    • Bioinformatics research for personalized medicine and cell therapy
  • Structural Biology Team
    • Protein structure modeling and refinement
    • Protein-ligand Docking and Virtual Screening
  • Systems Bioinformatics Team
    • Development of algorithms, tools, and DBs for systems bioinformatics
    • Network-based analysis of gene expression data
Achievements
  • In an effort to support bioinformatics and genomics research in Korea, we carry out multi-faceted tasks with emphases on (i) integrative system for national biomedical research information, (ii) analysis systems for high-throughput genomic sequence data, (iii) collection and systematic organization of omics data, (iv) infrastructure for systems network bioinformatics, (v) lung cancer multi-omics data production and integrative analysis, and (vi) research & education support and collaborative network.
Selected Publications
  • Namshin Kim (Co-corresponding) BMC Genomics. 14:519.
    • Whole-genome resequencing of Hanwoo (Korean cattle) and insight into regions of homozygosity
  • Sanghyuk Lee (Co-corresponding) Nucleic Acids Res. 41:D252-7.
    • miRGator v3.0: a microRNA portal for deep sequencing, expression profiling and mRNA targeting
  • ByungUk Lee (Co-corresponding) PLoS Genet. 9(2):1003229.
    • Genetic landscape of open chromatin in yeast
  • Sang Cheol Kim (First) PLoS One. 8(5):e63290.
    • Stouffer's test in a large scale simultaneous hypothesis testing
  • Jinhyuk Lee (Co-first) Process Biochem. 48(1):162-8.
    • Inhibition of tyrosinase by gastrodin: An integrated kinetic-computational simulation analysis