Synthetic Biology and Bioengineering Research Center_Korea Research Institute of Bioscience & BioTechnology

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Development of diagnosis/sensing devices and synthetic biological tools through the convergence of Bio-Nano-Chemical technologies

Development of novel proteins for diagnosis/sensing devices
Development of synthetic biology-based genetic circuits for sensing and controlling cellular metabolism
Construction of a biofab repository for designing and synthesizing customized proteins

researchers and research statement
Name	Research Fields
Seung-Goo Lee (Associate Director)	Synthetic biology, Protein engineering, Biomolecular imaging
Chul Ho Kim	Biorefinery and Bioenergy, Functional biomaterials, Bioprocess
Jung-Hoon Sohn	Yeast secretory production of recombinant proteins Yeast-based platform technology for bioenergy and biochemicals Lipase engineering for eco-friendly production of biodiesel
Doo-Byoung Oh	Protein therapeutics, Glycan analysis and remodeling
Heung-Chae Jung	Metabolic/enzyme engineering, Microbial physiology, Surface protein expression
Dae-Hee Lee	Synthetic biology, Metabolic engineering, Genome evolution and application
Sang Jick Kim	Phage-antibody library building, Production of protein medicine
Haseong Kim	Systems biology, Genetic circuit design
Soo-Jin Yeom	Protein/enzyme engineering, Synthetic Biology
Hyewon Lee	Bioimaging, Biosensors and Biochips
Bong Hyun Sung	Microbial genome engineering, enzyme engineering and artificial photosynthesis

Systems biology
- Integrative analysis of mult-omics data and in silico modeling and simulation of biological networks
Synthetic Biology
- Development of high-throughput enzyme screening system based on artificial genetic circuits
- Development of microbial cell factories implying intelligent control of cellular networks
- Synthetic biology-based development of high-value natural compounds
Novel materials for Bioconvergence
- Design and synthesis of sensor proteins customized for antibodies (e.g. sugar chain, peptide, toxicity)
- Development of novel bioconvergence proteins of diagnosis and sensing through artificial evolution of enzymes

Comprehensive understanding of whole-system of industrial microbes through integrative analyses of genome, transcriptome, proteome, phenome, and metablic/transcriptional networks
- Understanding of genome evolution and adaptation in a long-term experiment with Escherichia coli
- Development of microbial cell factories and analyses of signal transduction networks
Development of platform technologies of intelligent genetic circuits and bioconvergence
- Development of GESS(Genetic Enzyme Screening System) sensing a trace of enzyme activity from single cell/colony
- GESS-based high-throughput screening and artificial protein evolution of cellulase, lipase, amidase, etc
- Characterization of biosynthetic pathways of novel enzymes for the production of pharmaceuticals, natural compounds, and chemicals
Development of novel proteins for diagnosis/sensing devices
- Development of specific binding proteins for cytokine and chemicals through high-throughput screening of biomolecular interactions and its biosensor application
- Development of fluorescent probes for detection of fucosylated N-glycans
- Development of high sensitive FRET molecular sensor

- Biological Resource Center	- Primate Resource Center	- Korea Biosafety Clearing House
- Laboratory Animal Resource Center	- Futuristic Animal Resource & Research Center	- Biotech Policy Research Center
- Bio-Evaluation Center	- International Biological Material Research Center	- Korean Bioinformation Center
- Korea National Primate Research Center	- ABS Research Support Center	- National Research Safety Headquarter