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Metabolic Regulation Research Center

Metabolic Regulation Research Center
Objectives
Development of original technology that controls metabolic diseases by understanding of metabolic network
  • Understanding of metabolic network of major metabolic organs (fat, liver, muscle, cranial nerve, etc.)
  • Identification of metabolic organ regualation factor through omics analysis of metabolic organs
  • Finding out the signaling system and mechanism of metabolic disease regulation factor
  • Development of original technology that controls metabolic diseases including obese and diabetes
Researcher
researchers and research statement
Name Research Fields
Won Kon-Kim
(Associate Director)
  • Research on the regulation of adipocyte differentiation and thermogenesis
  • Research on trans-differentiation of adipocytes
  • Research on metabolic diseases
Kwang-Hee Bae
  • Identification of metabolic disease treatment targets and functional research using proteomics
  • Identification of stem cell differentiation and dedifferentiation related protein and functional research
Sang Chul Lee
  • Research on the mechanism of metabolism regulation related to stem cell differentiation
  • Identification of the protein related to metabolic disease based on the omics approach and investigation of its function
Myung Hee Kim
  • Research on the mechanism and control of molecular pathology based on convergence technology
Byoung-Chan Kim
  • Research on the isolation and identification of anaerobic human microorganisms and their clinical application
Young-Jun Park
  • Research on metabolic control and control of infectious disease using the macrophage, which is involved in innate immunity
Jungwon Hwang
  • Research on the pathogen-specific biochemical mechanism based on structural and cell biological approaches
Baek-Soo Han
  • Exploration of treatment for degenerative neural diseases, research on metabolic functions and identification of neural cell differentiation regulation factors
Hyun Seung Ban
  • Identification of new anticancer target molecules using chemical biology and development of function regulation materials
Kyoung Jin Oh
  • Understanding the insulin signal delivery system and energy metabolism of type 2 diabetes and obesity, and researching regulations
Eun-woo Lee
  • Research on the ubiquitin pathways in metabolic disease and cancer metabolism
  • Research on cell death pathways including apoptosis, necroptosis and ferroptosis
research areas
  • Research on the regulation of metabolic diseases
    • Identification of energy metabolic system in type 2 diabetes and obesity and research on regulation mechanism
    • Identification of regulation material related to transition from white adpose tissue to brown adipose tissue and research on function
    • Screening and functional research on metabolic disease regulation material based on low molecular compound or natural product
    • Analysis on the functional change of major metabolic organs and signal delivery system under the metabolic abnormality and improvement condition using animal model
    • Identification and functional research of network regulation factors among metabolic organs through omics analysis
  • Metabolic control research related to neurodegenerative diseases
    • Research on metabolomics and animal model related to neuron function and neurodegenerative diseases
  • Research on the mechanism of deterring diabetes and macular degeneration by macrophage
    • Research on the mechanism of controlling metabolism by macrophage
    • Identification of mechanism for deterring infectious diseases and signaling control by macrophage
  • Research on the mechanism of cancer metabolism regulation
    • Identification of target molecules related to cancer metabolism using compound and function regulation
Achievements
  • Research on the mechanism of differentiation control of white adipose tissue
    • Finding out the mechanism of controlling differentiation by white adipose tissue using phosphates yeast
    • Identification of factors that controls differentiation of white adipose tissue using analysis on proteome and finding out functions
    • Identification of factors that controls differentiation of white adipose tissue by acetylation of protein and finding out functions
  • Research on brown adipose tissue and conversion from white adipose tissue to brown adipose tissue
    • Finding out the role of phosphatase yeast in the generation of brown fat
    • Finding out the mechanism of brown fat differentiation regulation by Myostatin
    • Finding out the mechanism of brown adipose tissue differentiation regulation through analysis on proteome
    • Identification of protein that controls the conversion of white adipose tissue to brown adipose tissue and research on functions
  • Identification of new protein new drug target to treat neurodegenerative diseases
    • Identification of new drug target protein for neurodegenerative by analyzing changes of phosphorylated protein during the destruction of neuron
  • Finding out mechanism of infectious disease control through the iNOS control
    • Finding out mechanism of iNOS control by TXNIP
    • Finding out the deterrent effect of inflammation by iNOS control
  • Research on the possibility of controlling obesity and diabetes by controlling TXNIP
    • Finding out the role of TXNIP in obesity and diabetes
    • Finding out the signaling system of TXNIP in obesity and diabetese