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Metabolic Regulation Research Center

Metabolic Regulation Research Center
Objectives
Development of original technology that controls metabolic diseases by understanding of metabolic network
  • Understanding of metabolic network of major metabolic organs (fat, liver, muscle, cranial nerve, etc.)
  • Identification of metabolic organ regualation factor through omics analysis of metabolic organs
  • Finding out the signaling system and mechanism of metabolic disease regulation factor
  • Development of original technology that controls metabolic diseases including obese and diabetes
Researcher
    Click on the name
researchers and research statement
name research fields
Won Kon-Kim
/ Associate Director
  • Research on the regulation of adipocyte differentiation regulation and function, research on trans-differentiation of adipocyte and metabolic diseases
Kwang-Hee Bae
/ Principal Researcher
(Concurrent Position)
  • Identification of metabolic disease treatment target and functional research using proteomics
  • Identification of stem cell differentiation and de-differentiation related protein and functional research
Sang Chul Lee
/ Principal Researcher
  • Research on the mechanism of metabolism regulation related to stem cell differentiation
  • Identification of protein of metabolic disease based on omics and functions
Kim Myung Hee
/ Principal Researcher
  • Research on the mechanism and control of molecular pathology based on convergence technology
Byoung Chan Kim
/ Senior Researcher
  • Research on the isolation and identification of anaerobic human microorganisms and their clinical application
Jungwon Hwang
/ Senior Researcher
  • Research on the pathogen-specific biochemical mechanism based on structural and cell biological approaches
Baek Soo Han
/ Senior Researcher
  • Exploration of treatment for degenerative neural diseases, research on metabolic functions and identification of neural cell differentiation regulation factors
Ban Hyun Seung
/ Senior Researcher
  • Identification of new anticancer target molecule using chemical biology and development of function regulation materials
Park Young-Jun
/ Senior Researcher
  • Research on metabolic control and control of infectious disease using marcrophage which is involved in innate immunity
Kyoung Jin Oh
/ Senior Researcher
  • Finding out the insulin signal delivery system and energy metabolism regarding type 2 diabetes and obesity and research on regulation
Eun-woo LEE
/ Researcher
  • Research on control mechanism of metabolic diseases and cancer metabolism by protein ubiquitination
  • Research on control mechanism of apoptosis and necroptosis
research areas
  • Research on the regulation of metabolic diseases
    • Identification of energy metabolic system in type 2 diabetes and obesity and research on regulation mechanism
    • Identification of regulation material related to transition from white adpose tissue to brown adipose tissue and research on function
    • Screening and functional research on metabolic disease regulation material based on low molecular compound or natural product
    • Analysis on the functional change of major metabolic organs and signal delivery system under the metabolic abnormality and improvement condition using animal model
    • Identification and functional research of network regulation factors among metabolic organs through omics analysis
  • Metabolic control research related to neurodegenerative diseases
    • Research on metabolomics and animal model related to neuron function and neurodegenerative diseases
  • Research on the mechanism of deterring diabetes and macular degeneration by macrophage
    • Research on the mechanism of controlling metabolism by macrophage
    • Identification of mechanism for deterring infectious diseases and signaling control by macrophage
  • Research on the mechanism of cancer metabolism regulation
    • Identification of target molecules related to cancer metabolism using compound and function regulation
Achievements
  • Research on the mechanism of differentiation control of white adipose tissue
    • Finding out the mechanism of controlling differentiation by white adipose tissue using phosphates yeast
    • Identification of factors that controls differentiation of white adipose tissue using analysis on proteome and finding out functions
    • Identification of factors that controls differentiation of white adipose tissue by acetylation of protein and finding out functions
  • Research on brown adipose tissue and conversion from white adipose tissue to brown adipose tissue
    • Finding out the role of phosphatase yeast in the generation of brown fat
    • Finding out the mechanism of brown fat differentiation regulation by Myostatin
    • Finding out the mechanism of brown adipose tissue differentiation regulation through analysis on proteome
    • Identification of protein that controls the conversion of white adipose tissue to brown adipose tissue and research on functions
  • Identification of new protein new drug target to treat neurodegenerative diseases
    • Identification of new drug target protein for neurodegenerative by analyzing changes of phosphorylated protein during the destruction of neuron
  • Finding out mechanism of infectious disease control through the iNOS control
    • Finding out mechanism of iNOS control by TXNIP
    • Finding out the deterrent effect of inflammation by iNOS control
  • Research on the possibility of controlling obesity and diabetes by controlling TXNIP
    • Finding out the role of TXNIP in obesity and diabetes
    • Finding out the signaling system of TXNIP in obesity and diabetese
Outstanding Papers
  • Kwang-Hee Bae (Corresponding) Cell Mol. Life Sci. 67(13):2271-2281.
    • Annexin A4 interacts with the NF-kappaB p50 subunit and modulates NF-kappaB transcriptional activity in a Ca2+-dependent manner.
  • Kwang-Hee Bae (Corresponding) Oncogene. 28(12):1529-1536.
    • Far upstream element-binding protein-1, a novel caspase substrate, acts as a cross-talker between apoptosis and the c-myc oncogene.
  • Kwang-Hee Bae (Corresponding) Mol. Biol. Cell. 22(24):4883-4891.
    • RPTPu tyrosine phopshatase promotes adipogenic differentiation via modultion of p120 catenin phosphoryltion
  • Kwang-Hee Bae (Corresponding) J. Lipid Res. 53(9):1864-1876.
    • Acetylation of malate dehydrogenase 1 promotes adipogenic differentiation via activating its enzymatic activity.
  • Sang Chul Lee (Corresponding) Mol. Cell. Endocrinol. 416:70-76.
    • MKP kinase phosphatase 3 inhibits brown adipocyte differentiation via regulation of Erk phosphorylation.
  • Sang Chul Lee (Corresponding) Biomaterials. 51:119-128.
    • Stimulation of angiogenesis and survival of endothelial cells by human monoclonal Tie2 receptor antibody.
  • Won Kon Kim (First author) J. Cell. Sci. 122(22):4160-4167.
    • Regulation of adipogenic differentiation by LAR tyrosine phosphatase in human mesenchymal stem cells and 3T3-L1 preadipocytes.
  • Baek-Soo Han (First author) Proc. Natl. Acad. Sci. 112(28):8756-8761.
    • Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson's disease.
  • Hyun Seung Ban (First author) Angew. Chem. Int. Ed. Engl. 52(39):10286-10289.
    • Identification of malate dehydrogenease2 as a target protein of the hif-1 inhibitor LW6 using chemical probes
  • Kyoung-Jin Oh (First author) Cell. Metab. 9(3):240-251.
    • TORC2 regulates hepatic insulin signaling via a mammalian phosphatidic acid phosphatase, LIPIN1
  • Young-Jun Park (First author) PLoS Path. 9(10): e1003646.
    • TXNIP deficiency exacerbates endotoxic shock via the induction of excessive nitric oxide synthesis.
  • Sang Jun Lee (Co-corresponding author) Front Microbiol. 5:476.
    • Short-term differential adaptation to anaerobic stress via genomic mutations by Escherichia coli strains K-12 and B lacking alcohol dehydrogenase.
  • Sang Jun Lee (Co-corresponding) Metabol Eng. 18:44-52.
    • Genome-wide analysis of redox reactions reveals metabolic engineering targets for D-lactate overproduction in Escherichia coli
  • Jungwon Hwang (Co-first), and Myung Hee Kim (Co-corresponding) Proced Natl Acad Sci. 110:e2829-37.
    • Structural insights into the regulation of sialic acid catabolism by the Vibrio vulnificus transcriptional repressor NanR
  • Jungwon Hwang (First), and Myung Hee Kim (Corresponding) Nat Commun. 5:2958.
    • The structural basis for the negative regulation of thioredoxin by thioredoxin-interacting protein
  • Byoung-Chan Kim (Second) Proced Natl Acad Sci. 113:e762-71.
    • Dysbiosis-induced IL-33 contributes to impaired antiviral immunity in the genital mucosa
  • Byoung-Chan Kim (Corresponding) Gut Pathogens 8:3.
    • Whole genome sequencing of “Faecalibaculum rodentium” ALO17, isolated from C57BL/6J laboratory mouse feces