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Stem Cell Research Center

The Stem Cell Research Center (SCRC) aims to understand the fate transition phenomena between somatic and stem cells and to develop tissue-specific differentiation technology which can facilitate various researches such as disease modeling and new drug discovery as well as regenerative medicine. Additionally, the SCRC investigates stem cell-based in vitro evaluation system to replace animal models and to change the paradigm of conventional therapeutics development.
In order to meet these objectives, the SCRC is committed to :
- Understanding biological and molecular mechanism of cell fate transition between somatic and stem cells
- Providing stem cell based three-dimensional (3D) organoids model
- Modeling human diseases in vitro for biological and biochemical therapeutic development
- Developing 3D cell culture based-disease models and alternative methods of animal experiments

researchers and research statement
Name |
Research Fields |
Janghwan Kim (Associate Director) |
- Disease modeling and development of therapeutics for neural diseases
- Understanding reprogramming mechanism and developing new regenerative approach
|
Cho Rok Jung |
- Functional validation of disease related genes and development of therapeutics
- Development of 3 dimensional cell based disease model
|
Mi-Young Son |
- Disease modeling based on induced pluripotent stem cell
- Stem cell-based 3D gastrointestinal organoids as models of human development and disease
|
Myung Jin Son |
- Metabolic and mitochondrial regulation in cell fate transition
- Modeling normal- and disease-state livers using organoid system
|
Hyun-Soo Cho |
- Development of prediction pipeline for hPSC-derived cells
- Functional analysis of epigenetic modifiers in hPSC-derived cells
|
Jung Hwa Lim |
- Functional Analysis of disease related genes
- Development and evaluation of small molecule cancer drug
- Evaluation of therapeutic gene transfer for genetic disease
|
Hyun Mi Kang |
- Development of disease model based on 3-dimensional cells
- Research on generation/differentiation of kidney organoids
|
Kyung Hee Noh |
- Novel mechanism for ubiquitination enzyme
- Development of novel oral bioavailability method
|
Young-Joo Jeon |
- Molecular analysis of disease targets identified using patient iPSCs
- Proteomic analysis and identification of novel drug targets
|
- Finding out the biological and molecular mechanism of somatic cell/stem cell fate transformation
- Development of fate control/reprogramming core technology for somatic cell/stem cell
- Development of human disease modeling original technology based on stem cell
- Development of technology utilizing stem cell
- Verification of disease related gene function and development of original technology for treatment (synthetic compound/gene therapy)
- Development of disease model based on 3-dimensional cell

- Stem cells, Reprogramming, and Advanced Therapies
- Discovery of direct reprogramming phenomena using pluripotent factors
- Development of cell fate control technology through controlling mitochondria function
- Development of gene therapy based on gene function
- Disease modeling, Organoids, and Alternative methods of Animal experiments
- In vitro maturation of human pluripotent stem cell-derived intestinal organoids
- Development of computational prediction model for differentiation status of hPSC-derived cells
- Development of disease model based on 3 dimensional biosimilar culturing method and medicine effectiveness evaluation model
- Finding intestinal gene expression changes using organoids from Parkinson¡¯s disease iPSCs
- In vitro and in vivo imaging and tracking of intestinal organoids
- Research on GM1 gangliosidosis disease modeling using patient-oriented induced pluripotent stem cell
- Research on the targets related to diseases and development of therapeutics
- Identification of disease related target gene and verification of function
- Development of anticancer agents targeting new carcinogenic factors