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Laboratory Animal Resource Center

Laboratory Animal Resource Center
Laboratory Animal Resource Center
Objectives
The goal of our center is to establish a national infrastructures for laboratory animal resources and intramural service core for animal experimentations. For these purposes, we are collecting mouse resources, developing technologies, generating animal models for human diseases, and providing services for researchers in biomedical research fields. We have been collecting, preserving and distributing laboratory animal resources since 1984. We are developing technologies for the quality control of the laboratory animals, generating genetically engineered mice (GEM) and perform in vivo validation of genes associated with human diseases. Recently we have started international cooperation on development of GEM and it’s primary phenotyping to complete mammalian functional genome encyclopedia.
Researchers
researcher name and research fields
Name Research Fields
Hyoung-Chin Kim
(Associate Director)
  • Experimental Animal Medicine,
  • Toxicology of Drug Development
  • Health Safety of LMOs
Jong Soon Kang
  • Molecular Pharmacology
  • Efficacy evaluation of drug candidates
Ki-Hoan Nam
  • Laboratory Animal Science/Immunology
  • Reproductive engineering/Phenotyping of mutant mice
Chul-Ho Lee
  • Development and functional validation of animal models for human diseases
  • Genetic quality control of laboratory animals
Young-Suk Won
  • Bacteriology
  • Health monitoring of laboratory animals
Won-Kee Yoon
  • Veterinary Pathology
  • Genetic monitoring of laboratory animals Health Safety of LMO
Kyung-Shim Kim
  • Development and phenotyping of animal models for brain and neurological diseases
  • Discovery of bioactive materials for human brains and neurological diseases
Jung Hwan Hwang
  • Development of genetically altered laboratory animal models
  • Phenotyping of functional genes associated with metabolic diseases
Yong-Hoon Kim
  • Support for veterinary care and histopathological diagnosis
  • Functional phenotyping of cardiovascular and liver disease models
Hoyoung Ghang
  • Genome and phenome association study with model animals
  • Bioinformatics
Kyeong-Ryoon Lee
  • Drug Metabolism and Pharmacokinetics (DMPK)
  • PK-PD modeling and simulation
Oksung Moon
  • Management of SPF mouse resource
Kihoon Lee
  • Management of infected animals
Chang Woo Lee
  • Efficacy evaluation
Youngwon Seo
  • Management of infected animals
Myung Yeol Lee
  • In vivo medicine test
Dong Hui Choi
  • Management of animal model
research areas
  • Laboratory animal resources center
    • Collection, maintenance, and allocation of laboratory animal resources
    • Breeding and distribution of laboratory animal resources to research communities
    • Permanent preservation of laboratory animal resources as frozen resources
    • Establishment of a laboratory animal database
    • Quality control of laboratory animals
    • Phenotyping of mutant mice
    • Development of animal models for human diseases
    • Research supports for animal experiments
    • Functional validation of the genes associated with human diseases
    • Training of laboratory animal techniques
Achievements
  • A highly representative and the largest Korean laboratory animal resource bank
    • Deposits of laboratory animal resources: 465 strains
    • Distribution of laboratory animal resources: 6,252 animals
  • Quality control center for laboratory animals
    • Health monitoring: 2,840 animals
    • Mouse genotyping: 4,446 animals
    • Animal clearing: 41 strains
  • Training in laboratory animal techniques
    • The 35th Laboratory Animal Workshop was held on November 20-21, 2012
  • International cooperation with ICLASand AMMRA
    • ICLAS: International Council for Laboratory Animal Science
    • AMMRA: Asian Mouse Mutagenesis Resource Association
    • AMPC: Asia Mouse Phenotyping Consortium
    • IMPC: International Mouse Phenotyping Consortium
  • Supports for animal experiments
    • Pathological experiment: 37 cases
    • Hematological and biochemical analyses: 73 cases
    • Education service associated with animal ethics and appropriate animal experiments for animal experimenters : 4 times
research activities
  • In 2010, we published 17 papers concerning metabolic diseases (arising from our research using disease animal model resources) and registered 2 patents.
  • Also, we contributed 29 papers for publications resulting from KRIBB research into animal experiment support; including animal husbandry and pathological, hematological and biochemical analyses.