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Viral Infectious Disease Research Center

- Development of new vaccine technologies including subunit, genetic, and live attenuated vaccines capable of inducing cross-protective immunity
- Development of a new vaccine adjuvant using polymer (poly-gamma-glutamic acid) and investigation of its immune mechanism
- Basic research on influenza viruses, including surveillance and genetic characterization

- Development of new vaccine technologies, including subunit, genetic, and live attenuated vaccines against influenza viruses
- Several candidates of subunit vaccines have been developed via prokaryotic and eukaryotic protein expression systems, using the HA, M2, and NP antigens (Shim et al., PLoS ONE, 2011). We have succeeded in the design and mass production of novel vaccine candidates, and have currently evaluated their efficacies as vaccine candidates in animal models (Kim et al., J Infect Dis, 2012).
- Development of a new vaccine adjuvant using poly-gamma-glutamic acid and the investigation of its immune mechanism
- As an efficacious vaccine adjuvant candidate, we have developed poly-gamma-glutamic acid nanogel, which was previously reported to activate NK cells (Kim et al., J Immunol, 2007). Study of the immune mechanism of the adjuvant has revealed that it strongly induces both humoral and cellular immune responses (Lim et al., Small, 2011). The efficacy of the nanogel adjuvant has been evaluated in various animal models using a pandemic influenza A (H1N1) vaccine; the nanogel adjuvant significantly increased the vaccine efficacy compared with conventional adjuvants such as alum or squalene emulsion.
- Basic research on pandemic influenza, including surveillance and genetic characterization
- We have isolated influenza viruses from fecal samples of wild migratory birds and ducks in Korea. We have completely identified the positive isolates and have genetically and pathogenically characterized them (Nam et al., J. Virol 2011). In addition, we have evaluated in vitro and in vivo activities of some candidates of antiviral agents.
- Daesub Song (Co-First) J Gen Virol. 92(10):2350-5.
- Interspecies transmission of the canine influenza H3N2 virus to domestic cats in South Korea, 2010
- Haryoung Poo (Co-Corresponding) ACS Nano. 5(10):8230-40.
- Synthesis and high performance of magnetofluorescent polyelectrolyte nanocomposites as MR/near-infrared multimodal cellular imaging nanoprobes
- Haryoung Poo (Co-Corresponding) Chem Commun. 47(31):8889-91.
- Electrostatically assembled biocompatible polymer nanoparticles for MR/optical dual-modality imaging nanoprobes
- Haryoung Poo (Co-Corresponding) Small. 7(23):3281-6.
- Bioderived polyelectrolyte nanogels for robust antigen loading and vaccine adjuvant effects
- Jeong-Ki Kim & Haryoung Poo (Co-Corresponding) J Virol. 85(24):13271-7.
- Emergence of mammalian species-infectious and -pathogenic avian influenza H6N5 virus with no evidence of adaptation