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Anticancer Agent Research Center

Anticancer Agent Research Center
Objectives
Creation of leading material to develop innovative (first in class) anticancer drug and identification of new medicine target by understanding application point target of bioactive materials
  • Identification of new anticancer and cancer metastasis regulation materials
  • Identification of chemical biology based targe and understanding of function
  • Development of carcinogenesis control technology based on protein degradation
  • Synthesizing secondary metabolomics of microorganism and establishment of library for bioactive product of metabolism
Researcher
researchers and research statement
Name Research Fields
Jong Seog Ahn
(Associate Director)
  • Microbiology and cell biology
  • Chemical biology
Bo Yeon Kim
  • Cancer molecular cell biology
  • N-end rule pathway and protein degradation, autophagy
Sangku Lee
  • Organic chemistry
  • Organic synthesis, Medicinal Chemistry
Sungchan Cho
  • Virology of oncogenic viruses
  • Drug discovery and validation
Jae-Hyuk Jang
  • Microbial natural products chemistry
  • Marine natural products chemistry
  • Chemical biology
Young-Soo Hong
  • Natural product biosynthesis and engineering
  • Genome mining for new bioactive molecule discovery
Nak-Kyun Soung
  • Cancer cell biology
  • Cell division, anticancer drug discovery
Sung-Kyun Ko
  • Chemical biology
  • Target protein identification and target molecule interaction
Hyunjoo Cha-Molstad
  • Molecular cell biology
  • N-end rule pathway, autophagy and protein arginylation
Kyung Ho Lee
  • Molecular cell biology
  • Cell division, metastasis, ciliogenesis, spermatogenesis
In Ja Ryoo
  • Natural product chemistry
  • Bio-assay system
research areas
  • Identification of anti-cancer and cancer spread candidate materials
    • Identification of effective anticancer materials that control cancer cell specific metabolism
    • Understanding of movement and spread of cancer cell and identification of cancer spread deterrent
  • Understanding of chemical biological target of product of metabolism
    • Analysis on the working of microorganism’s new product of metabolism in a cell
    • Identification of new target molecule in a cell through chemical biological method
  • Exploration of materials that control movement of materials in melanosome in a cell
    • Development of bioactive material that controls autophagy and function of melanosome in a cell
  • Development of technology that controls carcinogenesis based on protein degradation
    • Identification of new anticancer target and anticancer agent by analyzing protein degradation route by N-end rule pathway
  • Microorganism metabolic engineering
    • Identification of the bioactive secondary product of metabolism of microorganism and establishment of library
    • Identification of bioactive secondary product of metabolism through microorganism synthesis biology engineering and metabolism control technology
Achievements
  • Identification of the material that deters movement and permeation of cancer cell
    • Discovery of new bioactive material that has new carbon structure of 5 heterogeneous circular shape in soil fungi isolate (fusarisetin A) and demonstrating that it is an bioactive material that has different mechanism from existing mechanism of cancer cell movement and permeation
  • Development of treatment for neural degenerative diseases, cancer, immune system related diseases by removing cytotoxic protein
    • Finding out the new working principle regarding the protein degradation and change process depending on external environmental change
  • Discovery of compound for skin cancer treatment which has less side effects
    • Discovery of anticancer material that has very low toxicity against the skin cancer derived from carcinogen and ultraviolet ray and synthesis of derivatives
  • Development of Hsp 90 deterrent by redesigning Geldanamycin biosynthesis gene
    • Development of heat shock protein (Hsp) 90 deterrents which is strong and less liver toxicity based on polyketide natural compound of geldanamycin through biosynthesis gene redesigning technology