±ÇÀº¼ö´ÜÀå
´ã´ç¾÷¹«
- ³ëÈÀ¶ÇÕ¿¬±¸´Ü ÃѰý Ã¥ÀÓÀÚ
- ³ëȵ¿¹°¸ðµ¨À» Ȱ¿ëÇÑ ³ëÈ ¹× ³ëÀμº Áúȯ ºÐÀÚ ±âÀü ¿¬±¸
¸ñÇ¥
- ³ëÈÀ¶ÇÕ¿¬±¸¼¾ÅÍ(ACRC)´Â ³ëÈÀÇ »ý¹°ÇÐÀû ¿ø¸®¸¦ ±Ô¸íÇϰí, ³ëÈ·Î ÀÎÇÑ ±â´É ÀúÇϸ¦ Áö¿¬¡¤¿ªÀü½Ã۱â À§ÇÑ Çõ½ÅÀû Àü·«À» °³¹ßÇϰí ÀÖ½À´Ï´Ù.
À̸¦ À§ÇØ DNA ¸ÞÆ¿È ±â¹Ý »ýü³ëÈ ½Ã°è °³¹ß, Ç÷¾× ÀÎÀÚ ±â¹Ý ¿ª³ëȹÙÀ̿÷ÎÁ÷½º, in vivo ³ëȼ¼Æ÷ÀÇ Á¤ÀÇ ¹× Á¦¾î ±â¼ú°³¹ß, Á¶Ç÷Áٱ⼼Æ÷ÀÇ ¿ª³ëȱâ¼ú°³¹ß ¹× ³ëÈÁö¿¬ µðÁöÅÐÇコÄÉ¾î ±â¼úÀ» °³¹ßÇϰí ÀÖ½À´Ï´Ù
¿¬±¸ºÐ¾ß
- ÈļºÀ¯Àüü ±â¹Ý DNA ¸ÞÆ¿·¹ÀÌ¼Ç ³ëÈ ½Ã°è °³¹ß
- ÈļºÀ¯Àüü µ¥ÀÌÅ͸¦ Ȱ¿ëÇÑ Àΰ£ ¹× ¸¶¿ì½º ³ëÈ ½Ã°è ¹× ³ëȼӵµ °³¹ß
- »ýü ³ëȽðè Á¤È®µµ¸¦ ³ôÀ̱â À§ÇÑ ´ÙÁß¿À¹Í½º ±â¹Ý »ý¹°ÇÐÀû ³ªÀÌ ¸ðµ¨¸µ
- Ç÷¾× À¯·¡ ³ëÈÁ¶ÀýÀÎÀÚ ¹ß±¼ ¹× À̸¦ Ȱ¿ëÇÑ ¿ª³ëÈ ±â¼ú °³¹ß
- Àü½ÅÀû Ç׳ëÈ È¿°ú¸¦ °¡Áö´Â Ç÷Àå ´Ü¹éÁú, miRNA, ´ë»çü ¹ß±¼
- ³ëÈ ¹× ³ëÀμºÁúȯ ±Øº¹À» À§ÇÑ Ç׳ëÈ ±â¼ú °³¹ß
- »ýü ³» ³ëȼ¼Æ÷ ¾ÆÆ®¶ó½º ±¸Ãà ¹× ³ëÈ ºÐÀÚ ±âÀü ¿¬±¸
- °ø°£ Àü»çüÇÐ (spatial transcriptomics)°ú ´Ü¹éÀ¯ÀüüÇÐ (proteogenomics)À» Ȱ¿ëÇÑ °íÇØ»óµµ ³ëȼ¼Æ÷ Áöµµ ±¸Ãà
- ´ÜÀϼ¼Æ÷ ¸ÖƼ¿À¹Í½º ºÐ¼®À» ÅëÇÑ ³ëȸ¦ À¯µµÇÏ´Â À¯ÀüÀÚ Á¶Àý ºÐÀÚ ³×Æ®¿öÅ© ±Ô¸í
- Ç¥ÀûÈµÈ ¼¼³î¸®Æ½½º ¹× ¸é¿ª ±â¹Ý Ä¡·áÁ¦ °³¹ß
- ³ëȼ¼Æ÷¸¦ Á¤¹ÐÇÏ°Ô Á¦°ÅÇϱâ À§ÇÑ Á¤¹Ð Ç¥Àû ³ëȼ¼Æ÷Á¦¾î±â¼ú ¼³°è
- ³ëȼ¼Æ÷¿¡ ´ëÇÑ ¸é¿ª Ȱ¼º ÀÎÀÚ¸¦ ã±â À§ÇÑ co-culture (°øµ¿¹è¾ç) ½ºÅ©¸®´× Ç÷§Æû °³¹ß
- Á¶Ç÷Áٱ⼼Æ÷(HSC) ¿ª³ëÈ ¿¬±¸
- HSC ³ëÈ °úÁ¤À» Á¤¹Ð ºÐÀÚ ±Ô¸í
- ´ÜÀϼ¼Æ÷ Ç÷§ÆûÀ» Ȱ¿ëÇÑ HSC ¿ª³ëÈ ¾à¹°ÀÇ ¹ß±¼ ¹× È¿´É °ËÁõ
¿¬±¸¼º°ú
- (ƯÇã) ³ëÀμº ±Ù°¨¼ÒÁõ Áø´Ü, Ä¡·á ¹°Áú, ³ëÈÁö¿¬ µðÁöÅÐ Ç÷§Æû Æ÷ÇÔ 20°Ç
- (±â¼úÀÌÀü) ³ëÀμº±Ù°¨¼ÒÁõ ¹ÙÀ̿÷ÎÁ÷½º 1°Ç (22¾ï), ³ëÈ À§ÇèÀÎÀÚ ÅëÇÕ°ü¸® µðÁöÅÐ Ä¡·á±â±â 2°Ç
¿ì¼ö³í¹®
- Emergence of CpG-cluster blanket methylation in aged tissues: a novel signature of epigenomic aging. 2025, Nucleic Acids Research
- Exercise-induced CLCF1 attenuates age-related muscle and bone decline in mice. 2025, Nature Communications
- ExermiR-129-3p Enhances Muscle Function by Improving Mitochondrial Activity Through PARP1 Inhibition, 2025, J Cachexia Sarcopenia Muscle
- Pelota-mediated ribosome-associated quality control counteracts aging and age-associated pathologies across species, 2025, PNAS
- Quasi-spatial single-cell transcriptome based on physical tissue properties defines early aging associated niche in liver, 2025, Nature Aging
- Age-dependent loss of Crls1 causes myopathy and skeletal muscle regeneration failure, 2024, Experimental Molecular Medicine
- Distinct characteristics of two types of alternative lengthening of telomeres in mouse embryonic stem cells, 2023, Nucleic Acids Research
- A new AMPK isoform mediates glucose-restriction induced longevity non-cell autonomously by promoting membrane fluidity, 2023, Nature Communications