The center aims to develop a big-data platform based on digital-based analytics of natural products in Korean medicinal plants and investigates natural drug candidates against chronic/rare diseases such as asthma/COPD, cancers and spinal muscular atrophy from plant sources.
Research Areas
Natural product chemistry for digital-based big data analytics
Drug candidate discovery for chronic respiratory diseases
Cancer immunotherapeutic agent screening
Discovery of drug candidate for the treatment of spinal muscular atrophy (SMA)
Isolation of natural drug candidates from domestical/international plant sources
Development of big-data platform for investigation of Korean medicinal plants
Construction of plant extract bank
Industrial research
Selected Publications
Comparison of secondary metabolite changes in Camellia sinensis leaves depending on the growth stage.
Food Control. 73:916-921.
Sei-Ryang Oh (Co-corresponding)
Artemisia argyi attenuates airway inflammation in ovalbumin-induced asthmatic animals.
J Ethnopharmacol. 209:108-115.
Hyung Won Ryu (Co-first)
Anti-inflammatory effect of stem bark of Paulownia tomentosa Steud. in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and LPS-induced murine model of acute lung injury.
J Ethnopharmacol. 210:23-30.
Sei-Ryang Oh (Corresponding)
Protective effect of polyacetylene from Dendropanax morbifera Leveille leaves on pulmonary inflammation induced by cigarette smoke and lipopolysaccharide.
J Funct Foods. 32:358-366.
Sei-Ryang Oh (Corresponding)
Protective effects of coumestrol on lipopolysaccharide-induced acute lung injury via the inhibition of proinflammatory mediators and NF-κB activation.
J Funct Foods. 34:181-188.
Hyung Won Ryu and Sei-Ryang Oh (Co-corresponding)
Potential anti-inflammatory effects of the fruits of Paulownia tomentosa.
J Nat Prod. 80(10):2659-2665.
Sei-Ryang Oh (Co-corresponding)
Melatonin suppresses fibrotic responses induced by cigarette smoke via downregulation of TGF-β1.
Oncotarget. 8(56):95692-95703.
Kyung Seop Ahn (Co-corresponding)
Lepistatins A-C, chlorinated sesquiterpenes from the cultured basidiomycete Lepista sordida.
