The goals of the center are to establish a national infrastructure for laboratory animal resources and a public/intramural service core for animal experimentations. For these purposes, we have been collecting mouse resources, developing quality control technologies, generating animal models for human diseases, and providing animal resources and services to researchers in biomedical research fields since 1984.
Recently, we started running a broad-based primary mouse phenotyping system which was established in cooperation with Korea Mouse Phenotyping Consortium (KMPC) and International Mouse Phenotyping Consortium (IMPC). In addition, we have established infrastructure for non-clinical evaluation and lead optimization of drug candidates using laboratory animals and have been providing research support to bio-health companies and researchers. Especially, our center has been designated as the exclusive center for mouse
resources by Ministry of Science and ICT in 2019.
Research Areas
Collection and maintenance of laboratory animal resources.
Production, expansion and distribution of laboratory animal resources for research communities.
Permanent preservation of laboratory animal resources as frozen resources.
Establishment of a laboratory animal database.
Quality control of laboratory animals (microbiological and genetic monitoring, microbiological clearing of animals contaminated with pathogens)
Phenotyping of mutant mice
Development of animal models for human diseases
Research support for animal experiments
Functional validation of the genes associated with human diseases
Provision of the basics of laboratory animal experimentation techniques to animal technicians and researchers
Establishment of infrastructure for non-clinical evaluation of new drug candidates
The largest laboratory animal resource bank in Korea
Center for quality control of laboratory animals
Training workshop for laboratory animal techniques
International cooperation with ICLAS, RIKEN and IMPC
Support for animal experiments
Non-clinical evaluation of drug candidates
Selected Publications
Importin-11 is essential for normal embryonic development in mice.
Int J Med Sci, 2020; 17(6): 815-823.
Ki-Hoan Nam (Corresponding)
Critical roles of E2f3 in growth and musculo-skeletal phenotype in mice.
Int J Med Sci, 2019; 16(12): 1580-1586.
Ki-Hoan Nam (Corresponding)
Inhibition of skin inflammation by scytonemin, an ultraviolet sunscreen pigment.
Mar Drugs. 18(6):E300.
Jong Soon Kang (Corresponding)
VEGF decoy receptor have superior anti-tumor effects through anti-EGFRs and targeted anti-antiogenic activities.
Biomaterials. 171:34-45.
Jong Soon Kang (Co-corresponding)
Model-based pharmacokinetic and pharmacodynamic analysis for acute effects of a small molecule inhibitor of diacylglycerol acyltransferase-1 in the TallyHo/JngJ polygenic mouse.
Xenobiotica. 49.7 (2019): 823-832.
Kyeong-Ryoon Lee (Corresponding)
Determination of motolimod concentration in rat plasma by liquid chromatography-tandem mass spectrometry and its application in a pharmacokinetic study.
J Pharmaceut Biomed. 179 (2020): 112987.
Kyeong-Ryoon Lee (Corresponding)
Small Heterodimer Partner Controls the Virus-Mediated Antiviral Immune Response by Targeting CREB-Binding Protein in the Nucleus.
Cell Rep. 2019; 27(7): 2105-2118.
Chul-Ho Lee (Co-corresponding)
Hepatocyte CREBH deficiency aggravates inflammatory liver injury following chemokine-dependent neutrophil infiltration through upregulation of NF-κB p65 in mice.
