The research goal of the center is to understand stem cell functions and disease mechanisms, in order to develop therapeutics for the treatment of human diseases. The center focuses on the generation of 3D human disease model systems using reprogrammed cells such as patient-derived induced pluripotent stem cells (iPSCs) for developing personalized and in vivo-mimetic disease models. In addition, the center developed an alternative method for animal testing, named as the ‘Networking Organoid Culture System (NOCS),' which involves different types of organoids, such as the intestine, liver, heart, brain, etc.
Research Areas
Development of core technologies involved in the cell fate change between somatic cells and stem cells
Modeling 3D human diseases based on stem cells, reprogramming, and organoid technology
In silico prediction systems for differentiation or determining the functional status of in vitro models
Development of a biomimetic 3D human tissue and networking platform for predicting drug toxicity and efficacy
Characterization of genes related to various diseases such as cancer and the development of therapeutic interventions such as small molecules, gene therapy, regenerative cells, and tissues
