Genome editing is a type of genetic engineering in which DNA is inserted, deleted, or corrected in the genome of a living organism using engineered nucleases or "molecular scissors.” These nucleases create site-specific double-strand breaks (DSBs) at a desired locus, and the induced double-strand breaks are repaired through nonhomologous end-joining or homologous recombination, which results in targeted gene corrections and ablations. The center aims to develop a new genome-editing platform and improve CRISPR system to provide a sophisticated tool for genome engineering. These genome-engineering tools are used for basic research, including the functional study of genetics, generation of model organisms, and gene therapy. The associated techniques can also be applied to various research and development fields, including gene delivery, stem cells, nanotechnology, and cell therapy.
Research Areas
Research on the advancement of gene editing technologies
Development of human mimicking mouse model using glyco-gene editing technology
Development of new epigenetic targets for epigenetic editing to prevent gastric carcinogenesis
Design, synthesis, and applications of new organic, supramolecular, and dendritic compounds for the diagnosis and treatment of diseases
Discovery of new migrastatic compounds
Identification of molecular subtype of bladder cancer associated with prognosis and immunotherapy
Macro-molecular mechanics studies related to proteins and chemical structures
Development of genome informatics technologies using deep learning
Development of a highly efficient CRISPR- Cpf1 system
Development of new nano-sized compounds for the diagnosis of cancer and retinal diseases
Development of new epigenetic targets in precancer and early gastric cancer
Development of a method to regulate epigenetic target genes using CRISPR system
Selected Publications
The mechanism of p53 rescue by SUSP4.
Angew Chem Int Ed Engl. 56(5):1278-1282.
Kyou Hoon Han (Corresponding)
Geranylnaringenin (CG902) inhibits constitutive and inducible STAT3 activation through the activation of SHP-2 tyrosine phosphatase.
Biochem Pharmacol. 142:46-57.
Byoung-Mog Kwon and Dong Cho Han (Co-corresponding)
Toward redesigning the PEG surface of nanocarriers for tumor targeting : impact of inner functionalities on size, charge, multivalent binding, and biodistribution.
Chem Sci. 8(7):5186-5195.
Yoonkyung Kim (Co-corresponding)
Potential forensic application of DNA methylation to identify individuals in a pair of monozygotic twins.
Forensic Sci Int - Genet. 6:e456-e457.
Yong Sung Kim (Corresponding)
Lectin from Sambucus sieboldiana abrogates the anoikis resistance of colon cancer cells conferred by N-acetylglucosaminyltransferase V during hematogenous metastasis.
