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Introduction
  • Synthetic Biology and Bioengineering Research Center (SBBRC) develops biological parts/devices and assembles them into practical and useful engineering tools. The key is the development of artificial genetic circuit devices using bio-parts, modeling/simulation and CRISPR technology. The range of potential applications encompasses, but is not limited to, biocatalyst/enzyme engineering, biofuel/chemical production, diagnostics and therapeutics. SBBRC recently became a member of Global Biofoundry Alliance (https://biofoundries.org) by establishing K-Biofoundry (https://kbiofoundry.org/index.html) to develop a robust and integrated biomanufacturing platform accessible to researchers across the private and public sectors.
Research Areas
  • Synthetic biology and genetic devices
  • System biology and bioinformatics
  • Microbial cell factory
  • Enzyme engineering for industrial biocatalysts
Head
Head
Name Position Tel / Email Detail
Dae Hee Lee Associate Director / Detail

Tel

042-879-8225

Email

dhlee@kribb.re.kr

Achievements
  • Development of artificial genetic circuits for highthroughput engineering
  • Development of biocatalysts for industrial applications
  • Development of CRISPRi system for intelligent metabolic flux control
  • Development of novel protein expression system
  • Development of deep learning technique for bioengineering
Selected Publications
  • Efficient transcriptional gene repression by type V-A CRISPR-Cpf1 from Eubacterium eligens.
    • ACS Synth Biol. 6(7):1273-1282.
    • Seung Goo Lee and Dae-Hee Lee (Co-corresponding)
  • Tunable control of an Escherichia coli expression system for the overproduction of membrane proteins by titrated expression of a mutant lac repressor.
    • ACS Synth Biol. 6(9):1766-1773.
    • Dae-Hee Lee (Co-first)
  • Synthetic vaccine nanoparticles target to lymph node triggering enhanced innate and adaptive antitumor immunity.
    • Biomaterials. 130:56-66.
    • Doo-Byoung Oh (Co-corresponding)
  • Leucine zipper-mediated targeting of multi-enzyme cascade reactions to inclusion bodies in Escherichia coli for enhanced production of 1-butanol.
    • Metab Eng. 40:41-49.
    • Seung Goo Lee and Dae-Hee Lee (Co-corresponding)
  • CRISPR interference-guided multiplex repression of endogenous competing pathway genes for redirecting metabolic flux in Escherichia coli.
    • Microb Cell Fact. 16(1):188.
    • Seung Goo Lee and Dae-Hee Lee (Co-corresponding)