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Introduction
  • Metabolic Regulation Research Center (MRRC) is designed to conduct basic scientific and translational research to control metabolic diseases, including diabetes, obesity, neurodegenerative disease, and cancer. The center aims to understand the mitochondria and cell signaling as well as metabolic network between organs (fat, liver,muscle, cranial nerve, etc.) through omics analysis and in vivo analysis. Further, the center also supports and promotes multidisciplinary studies to develop the core technology for controlling metabolic diseases.
Research Areas
  • Identification of metabolic energy system and regulatory mechanism of type 2 diabetes and obesity
  • Identification of regulatory material associated with the transition from white adipose tissue to brown adipose tissue and determine their functions
  • Screening and functional research of metabolic disease regulatory material based on the generation of a low molecular weight compound or natural product
  • Elucidating the pathophysiological mechanism of non-alcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH)
  • Research on Liver & Skeletal muscle energy metabolism in type 2 diabetes and aging
  • Analysis of the functional change in major metabolic organs and signal delivery systems under the metabolic abnormality and improvement conditions using animal models
  • Identification and functional research of network regulation factors among metabolic organs through omics analysis
Head
Investigator
Name Position Tel / Email Detail
Won Kon Kim Associate Director / Detail

Tel

042-860-4265

Email

wkkim@kribb.re.kr

Achievements
  • Research on the regulatory mechanism of adipocyte differentiation
  • Research on the in vivo function of white and brown adipose tissue
  • Elucidating the pathophysiological mechanism of non-alcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH)
  • Research on Liver & Skeletal muscle energy metabolism in type 2 diabetes and aging
  • Identification of new drug target protein to treat neurodegenerative diseases
  • Identification of new antivibriosis agent and investigation of related mechanism
Selected Publications
  • Synthesis and biological evaluation of kresoxim-methyl analogues as novel inhibitors of hypoxia-inducible factor (HIF)-1 accumulation in cancer cells.
    • Bioorg Med Chem Lett. 27(13):3026-3029.
    • Hyun Seung Ban (Co-corresponding)
  • Metabolic adaptation in obesity and type II diabetes : myokines, adipokines and hepatokines.
    • Int J Mol Sci. 18(1):e8.
    • Kwang-Hee Bae and Sang Chul Lee (Co-corresponding)
  • HDAC11 inhibits myoblast differentiation through repression of MyoD-dependent transcription.
    • Mol Cells. 40(9):667-676.
    • Sang Chul Lee (Co-corresponding)