Aging Research Center investigates the molecular mechanisms of the aging processes with regard to cellular changes and organ degeneration. The center is also responsible for developing fundamental technologies for the prevention of aging, aging-associated diseases and generation of therapeutics, using a multi-omics analysis, followed by functional validation.
Research Areas
Systems biology of sarcopenia and age-related diseases
Discovery of new genes involved in the aging process and study of associated signaling pathways
Discovery of rejuvenating factors to reverse the processes of aging
Functional identification of age-related genes using animal models
Development of drug candidates and biologics for the control of age-associated diseases
Identification of the rejuvenating factors that can reverse aging in old animals: analysis of serum factors and gut microbes by using proteomics tools and a genome-wide library, in order to achieve the slowing down of the aging process in old animals.
Discovering blood factors that change after exercise by multi-omics analysis in human and animal models: the study of the function of miRNA which is changed after exercise, in order to extend healthspan
Identification of new epigenetic markers related to muscle aging: analysis of retroelements by NGS analysis, in order to develop functional aging markers that can be utilized for aging diagnostic marker.
Finding novel telomere lengthening activity in nature: compare between diverse species by longread sequencing analysis to discover novel telomere lengthening mechanism
Selected Publications
Age-associated chromatin relaxation is enhanced in Huntington's disease mice.
Aging. 9(3):803-822.
Yong-Kook Kang (Co-corresponding)
Prediction of sarcopenia using a combination of multiple serum biomarkers.
Sci Rep. 8(1):8574.
Ki-Sun Kwon (Corresponding)
Comprehensive miRNA profiling of skeletal muscle and serum in induced and normal mouse muscle atrophy during aging.
J Gerontol A. 72(11):1483-1491.
Kwang-Pyo Lee (Co-first)
Forebrain-specific ablation of phospholipase Cγ1 causes manic-like behavior.
Mol Psychiatry. 22(10):1473-1482.
Yong Ryoul Yang (First)
Memory and synaptic plasticity are impaired by dysregulated hippocampal O-GlcNAcylation.
