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Immune Regulation Materials Research Center

Immune Regulation Materials Research Center
Objectives
  • Develop immune regulation materials using natural products
  • Develop natural biological materials for immune stimulation
  • Conduct research on the commercialization of functional materials
Researcher
    Click on the name
researchers and research statement
name research fields
Mun-Chual Rho
/ Associate Director
(Concurrent Position)
  • Development and research on the natural products that control inflammation and immunity
Kyungsook Jung
/ Researcher
  • Effectiveness evaluation and disease mechanism research using test animal disease model
Seung Jae Lee
/ Researcher
  • Development of functional material include the animal and plant from natural products
  • Evaluation of inflammatory disease using in vitro screening system
Chan Sun Park
/ Principal Technician
  • Separation, identification and storage of microorganism
Soyoung Lee
/ Senior Researcher
  • Natural product’s in vitro/ in vivo immunity toxicity evaluation and research on mechanism
Seung Woong Lee
/ Senior Researcher
  • Separation and refinement of active material and structure determination
research areas
  • Exploration and securement of effective bioactive materials
    • Separation and refinement of biological materials through efficient extraction and identify their structure
    • Extraction of functional materials originated from food microorganism and securement of effective compounds
    • Technical development for separation of functional protein/peptide and analysis on amino acid
  • Establishment and operation of system to verify efficacy of bioactive materials for immunity control
    • Exploration of active materials originated from biological resources and establishment of a library on active compounds
    • Evaluation of immunity of materials and efficacy of inflammation cell control using in vitro active search system
    • Establishment of in vivo model and evaluation of the safety from toxicity
  • Development of agricultural and bio resources (plant protection, microorganism-based pesticide material, feed additives)
    • Development of candidate materials into feed additives to control diseases of animals, fish and shells
    • Reduction of factors that cause damage to crop and development of alternatives to extinction chemicals
    • Securement of active materials from harmful bio resources and conduction of applied researches
  • Research on the industrialization of functional biological materials
    • Verification of repetitive toxicity test through safety evaluation and pre-clinical studies
    • Conduct of technology transfer to companies based on patents related to materials and activeness
    • Suggestion with respect to the possibility for a red ocean and a purple ocean through strategy on functional food except for therapy
Achievements
  • Securement of useful ingredients by separating and refining functional bioactive materials from bio resources and identifying their structure
  • Development of in vitro assay system utilizing a specific marker
  • Development of technology to utilize food microorganism from the industrial perspective
  • Establishment of test animal model for each disease and define a pre-clinical study system based on toxicity evaluation
Outstanding Papers
  • Mun-Chual Rho (Corresponding) J. Pharm. Biomed. Anal. 118:96-100, 2016.
    • Simultaneous determination of 3-O-acetyloleanolic acid and oleanolic acid in rat plasma using liquid chromatography coupled to tandem mass spectrometry
  • Mun-Chual Rho (Corresponding) Phytomedicine. 22(3):415-422. 2015.
    • Salvia plebeia extract inhibits the inflammatory response in human rheumatoid synovial fibroblasts and a murine model of arthritis.
  • Mun-Chual Rho (Corresponding) J Biol Pharm Bull. 38(1):66-74. 2015.
    • Purslane suppresses osteoclast differentiation and bone resorbing activity via inhibition of Akt/GSK3β-c-Fos-NFATc1 signaling in vitro and prevents lipopolysaccharide-induced bone loss in vivo.
  • Mun-Chual Rho (Corresponding) Rheumatology. 53(1):56-64. 2014.
    • Vigna angularis inhibits IL-6-induced cellular signalling and ameliorates collagen-induced arthritis.
  • Mun-Chual Rho (Corresponding) Toxicol Appl Pharm. 269(1):70-80. 2013.
    • Oleanolic acid acetate inhibits atopic dermatitis and allergic contact dermatitis in a murine model