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Microbiomics and Immunity Research Center
The mechanisms of microbe-host interactions and immune responses have been studied, and original technologies regarding disease control and reinforcement of immunity will be developed using gut microorganisms plus their fermentation products, and new bio-materials.
- Genetics based research on metabolomics and microbe-host interactions of gut microorganisms
- The pathology of gut microorganisms, microbial adaptation, and genome evolution under stressful conditions
- Isolation and clinical application of obligate anaerobes
- Exploration of new symbiotic microorganisms in the human and research on the application of beneficial symbiotic microorganisms
- Cellular and molecular mechanisms of host responses against infection
- Host-microbe interactions
- The role of the translational machinery in infection and immunity
- Structural and biochemical studies on the infectious diseases
- Microbial pathogenesis and host responses
- Virulence mechanisms of the MARTX proteins from Vibrio vulnificus
- Development of new vaccine technology
- Designing virus vaccine antigens and adjuvants
- Research on the mechanism of virus vaccines and vaccine immuno-adjuvants
- Regulation of anaerobic energy balance and mechanisms of metabolic stress
- Adaptive mutations of gut microorganisms under anaerobic stress
- Genome-wide analysis of redox reactions affecting anaerobic fermentation
- Cellular and molecular mechanisms of infectious diseases
- Pathogenesis of the Vibrio vulnificus NanR protein
- The role of the TXNIP protein in the NLRP3 inflammasome activation
- Development of new virus vaccine and vaccine adjuvants
- Evaluation of efficacy of virus vaccine and vaccine adjuvants and finding out the immunity mechanism of virus infection
- Sang Jun Lee (Co-corresponding author) Front Microbiol. 5:476.
- Short-term differential adaptation to anaerobic stress via genomic mutations by Escherichia coli strains K-12 and B lacking alcohol dehydrogenase.
- Sang Jun Lee (Co-corresponding) Metabol Eng. 18:44-52.
- Genome-wide analysis of redox reactions reveals metabolic engineering targets for D-lactate overproduction in Escherichia coli
- Jungwon Hwang (Co-first), and Myung Hee Kim (Co-corresponding) Proced Natl Acad Sci. 110:e2829-37.
- Structural insights into the regulation of sialic acid catabolism by the Vibrio vulnificus transcriptional repressor NanR
- Jungwon Hwang (First), and Myung Hee Kim (Corresponding) Nat Commun. 5:2958.
- The structural basis for the negative regulation of thioredoxin by thioredoxin-interacting protein
- Haryoung Poo (Co-corresponding) Angewandte Chem. 52:7684-9.
- Polymer nanomicelles for efficient mucus delivery and antigen-specific high mucosal immunity
- Haryoung Poo (Co-corresponding) Evid Based Compl Altern Med. 2013:635960.
- A single-center, randomized double-blind placebo-controlled study evaluating the effects of poly-gamma-glutamate on human NK cell activity after an 8-week oral administration in healthy volunteers
- Byoung-Chan Kim (Second) Proced Natl Acad Sci. 113:e762-71.
- Dysbiosis-induced IL-33 contributes to impaired antiviral immunity in the genital mucosa
- Byoung-Chan Kim (Corresponding) Gut Pathogens 8:3.
- Whole genome sequencing of ¡°Faecalibaculum rodentium¡± ALO17, isolated from C57BL/6J laboratory mouse feces