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Microbiomics and Immunity Research Center

Microbiomics and Immunity Research Center
Objectives
The mechanisms of microbe-host interactions and immune responses have been studied, and original technologies regarding disease control and reinforcement of immunity will be developed using gut microorganisms plus their fermentation products, and new bio-materials.
Researcher
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researchers and research statement
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Lee Sang Jun
/ Associate Director
  • Gut microorganism genetics, anaerobic metabolism, stress adaptation, genome evolution, and synthetic microbiology
Kim Myung Hee
/ Principal Researcher
  • Research on the mechanism and control of molecular pathology based on convergence technology
Haryoung Poo
/ Principal Researcher
  • Research on cell immunity, vaccine adjuvant and immunity improvement technology, establishment of virus recombination antigen and antibody
Byoung Chan Kim
/ Senior Researcher
  • Research on the isolation and identification of anaerobic human microorganisms and their clinical application
Jungwon Hwang
/ Senior Researcher
  • Research on the pathogen-specific biochemical mechanism based on structural and cell biological approaches
research areas
  • Genetics based research on metabolomics and microbe-host interactions of gut microorganisms
    • The pathology of gut microorganisms, microbial adaptation, and genome evolution under stressful conditions
  • Isolation and clinical application of obligate anaerobes
    • Exploration of new symbiotic microorganisms in the human and research on the application of beneficial symbiotic microorganisms
  • Cellular and molecular mechanisms of host responses against infection
    • Host-microbe interactions
    • The role of the translational machinery in infection and immunity
  • Structural and biochemical studies on the infectious diseases
    • Microbial pathogenesis and host responses
    • Virulence mechanisms of the MARTX proteins from Vibrio vulnificus
  • Development of new vaccine technology
    • Designing virus vaccine antigens and adjuvants
    • Research on the mechanism of virus vaccines and vaccine immuno-adjuvants
Achievements
  • Regulation of anaerobic energy balance and mechanisms of metabolic stress
    • Adaptive mutations of gut microorganisms under anaerobic stress
    • Genome-wide analysis of redox reactions affecting anaerobic fermentation
  • Cellular and molecular mechanisms of infectious diseases
    • Pathogenesis of the Vibrio vulnificus NanR protein
    • The role of the TXNIP protein in the NLRP3 inflammasome activation
  • Development of new virus vaccine and vaccine adjuvants
    • Evaluation of efficacy of virus vaccine and vaccine adjuvants and finding out the immunity mechanism of virus infection
Selected Publications
  • Sang Jun Lee (Co-corresponding author) Front Microbiol. 5:476.
    • Short-term differential adaptation to anaerobic stress via genomic mutations by Escherichia coli strains K-12 and B lacking alcohol dehydrogenase.
  • Sang Jun Lee (Co-corresponding) Metabol Eng. 18:44-52.
    • Genome-wide analysis of redox reactions reveals metabolic engineering targets for D-lactate overproduction in Escherichia coli
  • Jungwon Hwang (Co-first), and Myung Hee Kim (Co-corresponding) Proced Natl Acad Sci. 110:e2829-37.
    • Structural insights into the regulation of sialic acid catabolism by the Vibrio vulnificus transcriptional repressor NanR
  • Jungwon Hwang (First), and Myung Hee Kim (Corresponding) Nat Commun. 5:2958.
    • The structural basis for the negative regulation of thioredoxin by thioredoxin-interacting protein
  • Haryoung Poo (Co-corresponding) Angewandte Chem. 52:7684-9.
    • Polymer nanomicelles for efficient mucus delivery and antigen-specific high mucosal immunity
  • Haryoung Poo (Co-corresponding) Evid Based Compl Altern Med. 2013:635960.
    • A single-center, randomized double-blind placebo-controlled study evaluating the effects of poly-gamma-glutamate on human NK cell activity after an 8-week oral administration in healthy volunteers
  • Byoung-Chan Kim (Second) Proced Natl Acad Sci. 113:e762-71.
    • Dysbiosis-induced IL-33 contributes to impaired antiviral immunity in the genital mucosa
  • Byoung-Chan Kim (Corresponding) Gut Pathogens 8:3.
    • Whole genome sequencing of “Faecalibaculum rodentium” ALO17, isolated from C57BL/6J laboratory mouse feces