게시판

Principal Investigator
- Chul-Ho Lee, Laboratory Animal Resource Center / June 2013

R&D Background
- The cytochrome P450 (CYP2E1) has been known to be a key enzyme causing alcohol-induced liver injury through the generation of reactive oxygen species (ROS). This research was performed to investigate the role of nuclear hormone receptor ERRγ in the alcohol-mediated regulation of CYP2E1 and to examine the possibility to control alcohol-mediated oxidative stress and liver injury through an ERRγ inverse agonist.The cytochrome P450 (CYP2E1) has been known to be a key enzyme causing alcohol-induced liver injury through the generation of reactive oxygen species (ROS). This research was performed to investigate the role of nuclear hormone receptor ERRγ in the alcohol-mediated regulation of CYP2E1 and to examine the possibility to control alcohol-mediated oxidative stress and liver injury through an ERRγ inverse agonist.

Research Summary
- For chronic alcoholic hepatosteatosis study, C57BL/6J mice were administered alcohol for 4 weeks and an inverse agonist of ERRγ were given by oral gavage for the last 2 weeks of alcohol feeding. The treatment of an ERRγ inverse agonist significantly ameliorates chronic alcohol-induced liver injury in mice through inhibition of CYP2E1-mediated generation of ROS
Applied Cases and Effects
- This research has shown that suppression of alcohol-mediated oxidative stress and liver injury by and ERRγ-specific inverse agonist may be a novel and attractive therapeutic approach for the treatment of alcoholic liver disease.




Principal Investigator Chul-Ho Lee, Laboratory Animal Resource Center / June 2013 R&D Background The cytochrome P450 (CYP2E1) has been known to be a key enzyme causing alcohol-induced liver injury through the generation of reactive oxygen species (ROS). This research was performed to investigate the role of nuclear hormone receptor ERRγ in the alcohol-mediated regulation of CYP2E1 and to examine the possibility to control alcohol-mediated oxidative stress and liver injury through an ERRγ inverse agonist.The cytochrome P450 (CYP2E1) has been known to be a key enzyme causing alcohol-induced liver injury through the generation of reactive oxygen species (ROS). This research was performed to investigate the role of nuclear hormone receptor ERRγ in the alcohol-mediated regulation of CYP2E1 and to examine the possibility to control alcohol-mediated oxidative stress and liver injury through an ERRγ inverse agonist. Research Summary For chronic alcoholic hepatosteatosis study, C57BL/6J mice were administered alcohol for 4 weeks and an inverse agonist of ERRγ were given by oral gavage for the last 2 weeks of alcohol feeding. The treatment of an ERRγ inverse agonist significantly ameliorates chronic alcohol-induced liver injury in mice through inhibition of CYP2E1-mediated generation of ROS Applied Cases and Effects This research has shown that suppression of alcohol-mediated oxidative stress and liver injury by and ERRγ-specific inverse agonist may be a novel and attractive therapeutic approach for the treatment of alcoholic liver disease.